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TranscriptomicsSexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice
There is increasing appreciation for sexually dimorphic effects, but the molecular mechanisms underlying these effects are only partially understood. In the present study, we explored transcriptomics and epigenetic differences in the small intestine and colon of prepubescent male and female mice. In...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-57516 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Small Intestine data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39974 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine reveals fasting induces a biphasic adaptive metabolic response
Background; The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting. Results; In...
ORGANISM(S): Mus musculus 
2009-05-13 | E-GEOD-8019 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J strain.
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in the etiology of these metabolic disorders, a microarray study was performed on small intestines (SI) of C57BL/6J mice that were fed a high fat diet ...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-8582 | biostudies-arrayexpress
TranscriptomicsAltered gene expression in the small intestine of IE-Cpr-null mice
The NADPH-cytochrome P450 reductase (CPR) is essential for the functioning of microsomal cytochrome P450 (P450) monoxygenases. The biological functions of the CPR-dependent enzymes in the intestine are not known, despite the vast knowledge available on the biochemical properties of the various oxyge...
ORGANISM(S): Mus musculus 
2012-04-10 | E-GEOD-35293 | biostudies-arrayexpress
ProteomicsGlycoproteomic analysis of fucose-containing proteins in small intestine identified cryptdin-related sequence 1 as O-glycosylated proteins modified with α1,2-fucose
The modification of galactose with α1,2-fucose is involved in symbiosis with intestinal bacteria and elimination of pathogenic bacteria. It is postulated that α1,2-fucosylated mucin secreted from goblet cells is involved in defending an organism against infections, but the detailed molecular mechani...
ORGANISM(S): Mus Musculus (mouse) 
2020-11-05 | PXD022132 | JPOST Repository
ProteomicsSpatially resolved activity-based lipolytic proteomic profiles of the murine small intestine
Despite the crucial function of the small intestine for nutrient uptake our understanding of the molecular events underlying the digestive function is very rudimentary. For example, it has only recently become evident that not all absorbed triacylglycerol (TAG) is immediately secreted in the form of...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-11 | PXD019593 | Pride
Small intestine Lipases Activitz based proteomics Mouse 
TranscriptomicsTranscription profile of induced transgenic AhCreICDE/wt and AhCreEYFP/wt mice small intestine
Transgenic AhCreICDE/WT (n=3) and AhCreEYFP/WT (n=3) mice were induced with 3x80mg/kg betanapthoflavone and culled 24 hours later. RNA was extracted from the small intestine and hybridised to an Illumina mouseWG6 bead array
ORGANISM(S): Mus musculus 
2011-08-10 | E-MTAB-543 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Colon data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39973 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine following a four week diet high high in polyunsaturated fatty acids of marine origin
Dietary polyunsaturated fatty acids (PUFA) act as potent natural hypolipidemics and are linked to many health benefits in humans and in animal models. Mice fed long-term a high fat diet, in which medium-chain alpha linoleic acid (ALA) was partially replaced by long-chain docosahexaenoic (DHA) and ei...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-11936 | biostudies-arrayexpress
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