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MetabolomicsUntargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
The application of ketogenic diet (KD) (high fat/low carbohydrate/adequate protein) as an auxiliary cancer therapy is a field of growing attention. KD provides sufficient energy supply for healthy cells, while possibly impairing energy production in highly glycolytic tumor cells. Moreover, KD regula...
2019-10-08 | MTBLS1066 | MetaboLights
MetabolomicsMetabolomic profiling of mouse colorectal tumor tissues and fecal samples following bacterial intervention
This study investigated metabolic alterations in an AOM/DSS-induced mouse colorectal tumor model following bacterial intervention with Faecalibacterium prausnitzii and Peptostreptococcus stomatis. Targeted bile acid profiling and untargeted metabolomics were performed using LC-MS on colorectal tumor...
2026-09-24 | MTBLS15620 | MetaboLights
MetabolomicsImidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model
Ferroptosis is a form of regulated cell death that can be induced by inhibition of the cystine-glutamate antiporter, system xc-. Among the existing system xc- inhibitors, imidazole ketone erastin (IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially s...
2019-04-17 | MTBLS774 | MetaboLights
MetabolomicsMechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

Mechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

2025-08-01 | MTBLS12805 | MetaboLights
MetabolomicsMicrobial -Enzymatic Mucin Metabolic Relay Suppresses Tumor Progression in Apcmin/+ mice

Compelling evidence established the gut microbiota as a pivotal regulator of colorectal cancer (CRC) progression, although stage-specific mechanisms remain unclear. Our investigation in Apcmin/+ mice mapped tumor growth and microbial shifts across early, intermediate, and advanced stage...

2025-07-20 | MTBLS12754 | MetaboLights
MetabolomicsMicrobial -Enzymatic Mucin Metabolic Relay Suppresses Tumor Progression in Apcmin/+ mice

Compelling evidence established the gut microbiota as a pivotal regulator of colorectal cancer (CRC) progression, although stage-specific mechanisms remain unclear. Our investigation in Apcmin/+ mice mapped tumor growth and microbial shifts across early, intermediate, and advanced stage...

2025-07-24 | MTBLS12770 | MetaboLights
MetabolomicsCo-Housed Mice Reveal the Tumor-Promoting Potential of Akkermansia muciniphila
Specific pathogen-free laboratory mice are widely used in biomedical research; however, their neonatal-like physiological state often limits their ability to model adult human conditions. Here, we induced adult-like physiological characteristics in laboratory mice by co-housing them with naturally r...
2025-05-08 | MTBLS12361 | MetaboLights
MetabolomicsCo-Housed Mice Reveal the Tumor-Promoting Potential of Akkermansia muciniphila

Specific pathogen-free laboratory mice are widely used in biomedical research; however, their neonatal-like physiological state often limits their ability to model adult human conditions. Here, we induced adult-like physiological characteristics in laboratory mice by co-housing them with naturall...

2025-05-08 | MTBLS12360 | MetaboLights
MetabolomicsGDF15 hijacks B cells to fuel the lifeblood of tumor salvage pyrimidine synthesis
B cell-tumor crosstalk has emerged as a critical determinant of tumor progression; however, its role in metabolic reprogramming and therapeutic resistance remains poorly understood. Here, we uncover a metabolic feedback loop that drives resistance to dihydroorotate dehydrogenase (DHODH) inhibitors. ...
2026-09-27 | MTBLS15820 | MetaboLights
MetabolomicsMetabolic adaptations in an endocrine-related breast cancer mouse model unveil potential markers of tumor response to hormonal therapy
Not available
ORGANISM(S): Mus musculus 
ST001984 | MetabolomicsWorkbench
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