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TranscriptomicsLrig2 is required for maturation of peripheral nerves in the urinary bladder
Leucine-rich-repeats and immunoglobulin-like-domains (LRIG2) variants can occur in urofacial syndrome (UFS), an inherited disease characterised by functional bladder outlet obstruction. We aimed to define the pathobiology underlying UFS which we hypothesised would illuminate how the bladder becomes ...
ORGANISM(S): Mus musculus 
2020-04-27 | E-MTAB-6089 | biostudies-arrayexpress
TranscriptomicsGene expression study for effectiveness of nicotinamide using chemically-induced mouse bladder cancer model
The objective of this study was to evaluate the efficacy of nicotinamide in a N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced urinary bladder cancer model in mice, and to identify through gene expression profiling the molecular signatures of cancer prevention by nicotinamide. We used 20 mice fo...
ORGANISM(S): Mus musculus 
2011-12-12 | E-GEOD-21636 | biostudies-arrayexpress
MetabolomicsGut microflora alleviate immune response during E.coli-induced bladder cystits via AhR/MANF activation

In recent years, with the deepening of research on intestinal microbiota, we found intestinal microbiota plays an important role in host immune regulation and barrier maintenance through cross-talk between the microbiota and the host. New evidence suggests that disruption of the fragile balance w...

2023-07-11 | MTBLS5572 | MetaboLights
TranscriptomicsExpression data in UPEC cystitis in female C57BL/6 mice
Data defines for the first time a whole bladder transcriptome of UPEC cystitis in female C57BL/6 mice using genome-wide expression profiling to map early host response pathways stemming from UPEC colonization We used microarrays to detail the global programme of gene expression in UPEC UTI in mice W...
ORGANISM(S): Mus musculus 
2011-12-28 | E-GEOD-26509 | biostudies-arrayexpress
TranscriptomicsExpression data in UPEC cystitis in female CBA mice
Data defines for the first time a whole bladder transcriptome of UPEC cystitis in female CBA mice using genome-wide expression profiling to map early host response pathways stemming from UPEC colonization We used microarrays to detail the global programme of gene expression in UPEC UTI in mice Whole...
ORGANISM(S): Mus musculus 
2011-12-28 | E-GEOD-33210 | biostudies-arrayexpress
TranscriptomicsExpression data for UPEC and GBS cystitis in female C57BL/6 mice
Data defines for the first time a whole bladder transcriptome of UPEC cystitis in female C57BL/6 mice using genome-wide expression profiling and temporal analysis to map early host response pathways stemming from UPEC colonization We used microarrays to detail the global programme of gene expression...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-27575 | biostudies-arrayexpress
TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
TranscriptomicsE.coli Infected Bladder Samples (PBS, WT and 2 mutants)
Study of host response in mice to uropathogenic E. coli (UPEC) infection and the contribution of deletion of the Cnf and HlyA1 toxins to the host response. Mice were infected with UPEC in the bladder for 24 hrs and RNA was isolated from whole bladder to analyze on Agilent whole mouse 2-channel array...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-37959 | biostudies-arrayexpress
ProteomicsMouse Bladder LC-MS after bladder wall injection with Schistosoma haematobium eggs
Urogenital schistosomiasis (caused by Schistosoma haematobium) remains a major public health concern worldwide. In response to parasite egg deposition, the host bladder undergoes gross and molecular morphological changes relevant for disease manifestation. However, limited mechanistic studies to dat...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-23 | PXD029852 | Pride
Bladder  bladder wall injection  mice  proteomics  schistosoma haematobium  schistosomiasis Urogenital schistosomiasis 
TranscriptomicsTime course for bladder UCC development in UPII-SV40Tag mice
We have identified genes that are differentially expressed between the bladders of UPII-SV40Tag mice and their age-matched wild-type littermates at 3, 6, 20, and 30 weeks of age. These are ages that correspond to premalignant, carcinoma in situ, and early-stage and later stage invasive UCC, respecti...
ORGANISM(S): Mus musculus 
2010-08-28 | E-GEOD-23845 | biostudies-arrayexpress
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