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ProteomicsCerebrospinal Fluid Proteomics of Frailty
Frailty is defined as a clinical syndrome. It reflects a decrease in physiological reserve capacities that alters the mechanisms of adaptation to stress. Its clinical expression is modulated by biological, physiological, social and environmental changes. Thus, the accumulation of declines in these m...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD043497 | Pride
Lcr proteomics frailty 
ProteomicsCerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system
Narcolepsy type 1 (NT1) is a rare, chronic and disabling neurological disease causing excessive daytime sleepiness and cataplexy. NT1 is characterized pathologically by an almost complete loss of neurons producing the orexin neuropeptides in the lateral hypothalamus. Genetic and environmental factor...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD041093 | Pride
Neuroimmunology Coagulation system Cerebrospinal fluid Complement system Immune response Narcolepsy type 1 Proteomics 
ProteomicsPI3Kinase Isoforms in Pancreatic cancer
Pancreatic ductal adenocarcinoma is one of the most lethal cancers, with a 5 year-survival rate below 5%. Lack of curative treatment and failure of targeted therapies urge the need to identify novel efficient therapeutic strategy. Achievement of this goal will be obtained through the identification ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD008410 | Pride
Pi3k signaling pathway isoforms 
ProteomicsFranco-Swiss HPP project (Chromosomes 2 and 14)
The dataset is a concatenation of nanoLC-MS/MS analyses performed on different sample types/sample preparations of human proteins on various instrumental platforms in the laboratory. A franco-swiss collaboration to identify missing human proteins on chromosomes 2 and 14 in the frame of the Human Pro...
ORGANISM(S): Homo sapiens (Human) 
2015-07-17 | PXD002131 | Pride
Homo sapiens (human) 
Proteomicsyeast-UPS1 standard LC-MS/MS dataset
Proteomic workflows based on nanoLC-MS/MS data-dependent-acquisition analysis have progressed tremendously in recent years due to the technical improvement of mass spectrometers, and now allow to extensively characterize complex protein mixtures. High-resolution and fast sequencing instruments have ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2015-12-01 | PXD001819 | Pride
Yesat Ups1 Label-free quantification Lc-ms/ms 
ProteomicsProMetIS: deep phenotyping of mouse models by proteomics and metabolomics
The ProMetIS dataset corresponds to the proteomic and metabolomic analysis of mouse lines lacking the LAT (linker for activation of T cells; OMIM: 602354) or MX2 gene (MX dynamin-like GTPase 2; OMIM: 147890), as well as the control (WT) line. Besides its role in T-cell receptor (TCR) signaling (Ronc...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-11 | PXD028550 | Pride
Proteiomics metebolomics 
ProteomicsConnectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney disease
While blocking the renin angiotensin aldosterone system (RAAS) has been the main therapeutic strategy to control diabetic kidney disease (DKD) for many years, 25-30% of diabetic patients still develop the disease. In the present work we adopted a system biology strategy to analyze glomerular protein...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-17 | PXD018728 | Pride
Quantitative proteomics Nephropathy Diabetic kidney disease 
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
ProteomicsQuest for missing proteins in the human spermatozoa: an update
Here, we report work as part of C-HPP initiatives on chromosomes 14 (France) and 2 (Switzerland) aiming to identify missing proteins in ejaculated human spermatozoa using multiple MS-based and antibodies-based validation approaches
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080826 | MassIVE
ProteomicsFranco-Swiss HPP project (Chromosomes 2 and 14)
The dataset is a concatenation of nanoLC-MS/MS analyses performed on different sample types/sample preparations of human proteins on various instrumental platforms in the laboratory. A franco-swiss collaboration to identify missing human proteins on chromosomes 2 and 14 in the frame of the Human Pro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080273 | MassIVE
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