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ProteomicsRegulation of circulating mannosylated proteome by macrophage mannose receptor, Mrc1
Abundance of secreted proteins is tightly regulated in circulation, and its dysregulation forms a basis for development of pathology. N-glycosylation has been shown to be a decisive factor in determining the half-life of these proteins. Exoglycosidases remodel the proteins and exposure of cryptic l...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-06-11 | PXD059742 | Pride
Plasma Mrc1 Mannosylated proteins Sepsis 
TranscriptomicsNext Generation Sequencing identifies Cdh11 and Mrc1 as novel translational biomarkers of kidney fibrosis
Chronic kidney disease (CKD) is the gradual, asymptomatic loss of kidney function and current tests only identify it when significant loss has already happened. Using RNA sequencing in a mouse model of folic acid (FA) induced nephropathy, here we report the identification of 10 genes that track kidn...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-65267 | biostudies-arrayexpress
ProteomicsMrc1 facilitates epigenetic inheritance through proper parental histone segregation
Chromatin-based epigenetic memory relies on the equal distribution of parental histone tetramers, which serve as templates for duplicating parental chromatin, to newly synthesized daughter DNA strands. Histone chaperones within the replisome, such as the histone binding domains (HBDs) of Mcm2 and Po...
ORGANISM(S): Schizosaccharomyces Pombe (ncbitaxon:4896) 
2023-07-16 | MSV000092452 | MassIVE
GenomicsMrc1 facilitates epigenetic inheritance through proper parental histone segregation
Mrc1 facilitates epigenetic inheritance through proper parental histone segregation
PRJNA996182 | ENA
GenomicsSaccharomyces cerevisiae S288C
Saccharomyces cerevisiae swr1, mrc1, mrc1-1-843, mrc1 swr1, mrc1-1-843 swr1 sGCR isolate sequencing
PRJNA428375 | ENA
TranscriptomicsGene expression profiles of tumor-associated macrophages (TAMs) overexpressing miR-511-3p
Hematopoietic stem/progenitor cells (HS/PCs) were transduced with lentiviral vectors overexpressing OFP and either miR-511-3p or a control, mutated miRNA sequence (miR-511-3p-mut). The transduced HS/PCs were then transplanted in recipient C57BL/6 mice. Tumors (Lewis lung carcinomas, LLC) were inject...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-34903 | biostudies-arrayexpress
UnknownMrc1 regulates parental histone segregation and heterochromatin inheritance.
Not available
S-EPMC11414769 | biostudies-literature
GenomicsMus musculus
Mrc1+ Macrophage RNAseq
PRJNA1058634 | ENA
UnknownInhibition of Microglial TGFβ Signaling Increases Expression of Mrc1.
Not available
S-EPMC7137652 | biostudies-literature
GenomicsMrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast
How early- and late-firing origins are selected on eukaryotic chromosomes is largely unknown. Here we show that Mrc1, a conserved factor required for stabilization of stalled replication forks, selectively binds to the early-firing origins in a manner independent of Cdc45 and Hsk1 kinase in fission ...
ORGANISM(S): Schizosaccharomyces pombe 
2011-03-26 | GSE28182 | GEO
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