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ProteomicsMST4 promotes MRC2 activity to drive osteosarcoma proliferation
Osteosarcoma is one of the most common types of orthopedic malignancies with an accelerated disease progression and poor prognosis.The purpose of this study was to further investigate the function of Serine/threonine protein kinase 4(MST4) in osteosarcoma and its underlying mechanisms. The expressio...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD034216 | Pride
Mrc2 Mst4 Osteosarcoma proliferation 
GenomicsDeficiency of the Collagen Endocytic Receptor MRC2 Accelerates Mouse Lung Fibroblast Proliferation
Deficiency of the Collagen Endocytic Receptor MRC2 Accelerates Mouse Lung Fibroblast Proliferation
PRJNA1233307 | ENA
TranscriptomicsDeficiency of the Collagen Endocytic Receptor MRC2 Accelerates Mouse Lung Fibroblast Proliferation
Mannose receptor C type 2 (MRC2) is highly expressed in the lung and is the major endocytic receptor for the internalization and degradation of collagen in mesenchymal cells. Using Mrc2 knockout (KO) mice, we previously showed that MRC2 is required for efficient clearance of collagen in bleomycin-in...
ORGANISM(S): Mus musculus 
2025-10-31 | GSE291404 | GEO
GenomicsInherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility [fibroblast]
Inherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility [fibroblast]
PRJNA1184719 | ENA
GenomicsInherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility
Inherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility
PRJNA1206967 | ENA
UnknownMacrophage MRC2 deficiency mitigates HFD-induced MASLD by downregulating CD147-regulated TNF-α production.
Not available
S-EPMC12682121 | biostudies-literature
GenomicsInherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility [atrial tissue]
Inherited Variant in MRC2 Causes Cardiac Fibroblast Dysfunction and Increases Atrial Fibrillation Susceptibility [atrial tissue]
PRJNA1184722 | ENA
UnknownDifferential Expression of ARG1 and MRC2 in Retinal Muller Glial Cells During Autoimmune Uveitis.
Not available
S-EPMC11853277 | biostudies-literature
UnknownBioinformatics and functional experiments reveal that MRC2 inhibits atrial fibrillation via the PPAR signaling pathway.
Not available
S-EPMC10636429 | biostudies-literature
UnknownRare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome.
Not available
S-EPMC11335451 | biostudies-literature
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