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ProteomicsA truncated MRE11 form induced by SPRTN is deficient in DNA repair and radiosensitises cancer cells
he human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses 3’-5’ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associated with...
ORGANISM(S): Homo sapiens (Human) 
2021-02-23 | PXD017964 | Pride
C-terminal truncation Mre11 cleavage Mre11 Dna repair Sprtn 
UnknownMre11-Rad50 oligomerization promotes DNA double-strand break repair.
Not available
S-EPMC9061753 | biostudies-literature
UnknownSPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells.
Not available
S-EPMC7870818 | biostudies-literature
UnknownXrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex.
Not available
S-EPMC5123801 | biostudies-literature
UnknownLRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex.
Not available
S-EPMC8824468 | biostudies-literature
GenomicsGenome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice
The Mre11-Rad50-Nbs1 (MRN) complex recognizes and processes DNA double-strand breaks for homologous recombination by performing short-range removal of 5ʹ strands. Endonucleolytic processing by MRN requires a stably bound protein at the break site—a role we postulate is played by DNA-dependent protei...
ORGANISM(S): Homo sapiens 
2023-09-18 | GSE218590 | GEO
Genomics
Mre11-Rad50-Xrs2 nicking
PRJNA821913 | ENA
UnknownPhysiological protein blocks direct the Mre11-Rad50-Xrs2 and Sae2 nuclease complex to initiate DNA end resection.
Not available
S-EPMC5795779 | biostudies-literature
UnknownMRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells.
Not available
S-EPMC5643552 | biostudies-literature
UnknownSae2 controls Mre11 endo- and exonuclease activities by different mechanisms.
Not available
S-EPMC11341764 | biostudies-literature
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