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TranscriptomicsMre11 suppresses replication stress and gene amplification proficiency
Gene amplification, copy-number increases of particular genes and surrounding genomic segments, promotes cancer progression and acquired therapy resistance. Thus, understanding genetic traits that confer gene amplification proficiency is important. The primary step for gene amplification is sponta...
ORGANISM(S): Cricetulus griseus 
2015-03-05 | E-GEOD-59487 | biostudies-arrayexpress
ProteomicsA truncated MRE11 form induced by SPRTN is deficient in DNA repair and radiosensitises cancer cells
he human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses 3’-5’ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associated with...
ORGANISM(S): Homo sapiens (Human) 
2021-02-23 | PXD017964 | Pride
C-terminal truncation Mre11 cleavage Mre11 Dna repair Sprtn 
TranscriptomicsTranscription profiling of S. cerevisiae mre11, rad50 and spo11 mutants in premeiosis and meiotic prophase
Mre11, together with Rad50 and Xrs2/NBS, plays pivotal roles in homologous recombination, repair of DNA double strand breaks (DSBs), activation of damage-induced checkpoint, and telomere maintenance. Using DNA microarray assays to analyze yeast mutants (mre11delta, rad50delta, and spo11Y135F) defect...
ORGANISM(S): Saccharomyces cerevisiae 
2007-10-23 | E-GEOD-6620 | biostudies-arrayexpress
TranscriptomicsMRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers.
We have performed bioinformatic approaches to identify the level of enrichment between gene expression profiles characterizing MSI tumors and gene changes induced in vitro by the PARP-1 inhibitor Phenanthridinone and others using the Connectivity Map tool. In a first step, we have anyzed the express...
ORGANISM(S): Homo sapiens 
2011-04-07 | E-GEOD-26682 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human DU-145, PC-3MM2 cell lines treated with irradiation reveals Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
ORGANISM(S): Homo sapiens 
2009-05-13 | E-MEXP-2172 | biostudies-arrayexpress
TranscriptomicsMRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts
Rad50 is a component of the conserved MRE11-RAD50-NBS1 (MRN) complex, which functions in genome stability and the cell’s ability to deal with stalled DNA replication forks. We identified Rad50 as a factor important for R-loop tolerance and thus mapped DNA:RNA hybrids in Rad50KO cells and compare the...
ORGANISM(S): Saccharomyces cerevisiae 
2019-10-31 | E-MTAB-7885 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of Deletion RAD50, MRE11, XRS2
Deletion mutants of the yeast MRX complex (Rad50, Mre11 and Xrs2) were studied for gene expression levels. Significant difference in expression levels was observed in genes pertaining to DNA damage, cell cycle etc. as compared to the BY4741 wild type. Organism : Saccharomyces cerevisiae , Custom Sac...
ORGANISM(S): Saccharomyces cerevisiae 
2015-12-31 | E-GEOD-48538 | biostudies-arrayexpress
ProteomicsGFI1 facilitates efficient DNA repair by regulating PRMT1-dependent methylation of MRE11 and 53BP1
GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GF...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008897 | Pride
Dna repair gfi1 prmt1 methylation mre11 53bp1 
Proteomicsp97/VCP inhibition radiosensitises cancer cells through excessive MRE11-dependent DNA end resection
Cancer cells are under constant proteotoxic stress and have an increased genomic instability. They therefore rely on upregulation of protein homeostasis and the DNA damage response (DDR) for survival. The ubiquitin-dependent ATPase p97 is a central component of the ubiquitin-proteasome degradation s...
ORGANISM(S): Homo sapiens (Human) 
2021-05-18 | PXD016279 | Pride
Single-strand annealing Bladder cancer Dna double-strand break repair Proteasomal degradation Dna damage Ubiquitin Cb-5083 Homologous recombination Mre11 P97 
GenomicsMRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability
MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability
PRJNA1363211 | ENA
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