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ProteomicsCytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA
The cytotoxic mechanisms of thymidylate synthase inhibitors, such as the multitarget antifolate pemetrexed, are not yet fully understood. Emerging evidence indicates that combining pemetrexed with histone deacetylase inhibitors (HDACi) may enhance therapeutic efficacy in non-small cell lung cancer (...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD051824 | Pride
Ber Double strand breaks Base excision repair Histone deacetylase Ap Dihydrofolate reductase Dutpase dut Dhfr Apyrimidinic Deoxyuridine triphosphate nucleotide hydrolase Gart Trifunctional purine biosynthetic protein adenosine 3 Hdac Hdaci Dsb 
TranscriptomicsRNA-seq of combinatory treatment of gemcitabine+UVI5008 and gemcitabine+MS275 in human pancreatic adenocarcinoma human cell lines
Epigenetic modifications could drive some of the molecular events implicated in proliferation, drug resistance and metastasis of pancreatic ductal adenocarcinoma (PDAC). Thus, epigenetic enzyme inhibitors could be the key to revert those events and transform PDAC into a drug-sensitive tumor.We have ...
ORGANISM(S): Homo sapiens 
2022-07-01 | E-MTAB-11922 | biostudies-arrayexpress
UnknownHDAC inhibitor MS275 reprograms metabolism to induce differentiation and suppress proliferation in hepatocellular carcinoma.
Not available
S-EPMC12479291 | biostudies-literature
UnknownMS275 as Class I HDAC inhibitor displayed therapeutic potential on malignant ascites by iTRAQ-based quantitative proteomic analysis.
Not available
S-EPMC8783488 | biostudies-literature
TranscriptomicsRNA sequencing comparing SCN CSF3R-d715 RUNX1-D171N (RHD) treated with the HDAC inhibitor MS275, octyl-(R)-2hydroxyglutarate (2HG) or solvent control (DMSO)
Effects of TET2 on repressing inflammation have been assigned to its methylcytosine dioxygenase activity, but also to its ability to recruit HDAC-mediated repressor activity to pro-inflammatory genes. To discriminate between the two above-proposed functions of TET2, we asked how inhibition of its en...
ORGANISM(S): Homo sapiens 
2020-08-24 | E-MTAB-9374 | biostudies-arrayexpress
GenomicsRNAseq of U87 treated with bulk control/0.5mM 8-cpt-cAMP/1nM MS275 or a combination
RNAseq of U87 treated with bulk control/0.5mM 8-cpt-cAMP/1nM MS275 or a combination
PRJNA663633 | ENA
TranscriptomicsRNAseq of U87 treated with bulk control/0.5mM 8-cpt-cAMP/1nM MS275 or a combination
Transcriptomics revealed that the combination of 8-cpt-cAMP and MS275 could maximize the glioma differentation compared to control or use either drug alone
ORGANISM(S): Homo sapiens 
2023-03-15 | GSE158015 | GEO
GenomicsRNAseq of U87/over-expressed DPF3 U87 treated with bulk control/0.5mM 8-cpt-cAMP combination with 1nM MS275 for 48hrs
RNAseq of U87/over-expressed DPF3 U87 treated with bulk control/0.5mM 8-cpt-cAMP combination with 1nM MS275 for 48hrs
PRJNA663874 | ENA
TranscriptomicsRNAseq of U87/over-expressed DPF3 U87 treated with bulk control/0.5mM 8-cpt-cAMP combination with 1nM MS275 for 48hrs
Transcriptomics revealed that the combination of 8-cpt-cAMP and MS275 could maximize the glioma differentation compared to control or use either drug alone
ORGANISM(S): Homo sapiens 
2020-09-17 | GSE158065 | GEO
TranscriptomicsU937 miR-194-5p (UmiR-194-5p) vs U937 miR-194-5p (UmiR-194-5p) treated with MS275 (SNDX 275;Entinostat)
Transcriptional profiling of U937 miR-194-5p (UmiR-194-5p) vs U937 miR-194-5p (UmiR-194-5p) treated with MS275 (SNDX 275;Entinostat) for 24 h at 5uM concetration
ORGANISM(S): Homo sapiens 
2017-05-22 | GSE73647 | GEO
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