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ProteomicsTOPBP1 Shapes XY Silencing Dynamics Independently of Sex Body Formation to Ensure Male Fertility
In mammals and several other taxa, the ability of males to cope with the limited synapsis of the X and Y chromosomes during prophase I of meiosis relies on the process of meiotic sex chromosome inactivation (MSCI). Components of the somatic DNA damage response machinery, including ATR, TOPBP1, MDC1 ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-02-09 | PXD042199 | Pride
Topbp1 Male meiosis Mice Msci and xy silencing 
TranscriptomicsTranscription profiling of mouse germline during spermatogenesis reveals X and Y occupy a novel compartment in the post-meiotic spermatid and adopt a non-Rabl configuration
In mammals, the X and Y chromosomes are subject to meiotic sex chromosome inactivation (MSCI) during prophase I in the male germline, but their status thereafter is currently unclear. An abundance of X-linked spermatogenesis genes has spawned the view that the X must be active [1-8]. On the other ha...
ORGANISM(S): Mus musculus 
2007-12-07 | E-GEOD-4193 | biostudies-arrayexpress
UnknownA TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.
Not available
S-EPMC10942628 | biostudies-literature
TranscriptomicsNucleolar migration regulates meiotic sex chromosome inactivation via phase separation during mammalian spermatogenesis
During spermatogenesis, the unsynapsed XY chromosomes undergo meiotic sex chromosome inactivation (MSCI) and form a heterochromatic XY body. Defects in MSCI lead to meiotic arrest and male infertility. Although DNA damage response (DDR) factors are established as key initiators of MSCI, how transcri...
ORGANISM(S): Mus musculus 
2026-02-11 | GSE196779 | GEO
UnknownLARP7 is required for sex chromosome silencing during meiosis in mice.
Not available
S-EPMC11620648 | biostudies-literature
TranscriptomicsRole of LARP7 in meiotic sex chromosome silencing
Meiotic sex chromosome inactivation (MSCI) is an essential event in meiotic progression in mammalian spermatogenesis. We found that La Ribonucleoprotein 7 (LARP7) is involved in MSCI. LARP7 plays a role in fetal germ cells to promote their proliferation, but is once abolished in postnatal gonocytes ...
ORGANISM(S): Mus musculus 
2024-10-01 | GSE261526 | GEO
UnknownSilencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation.
Not available
S-EPMC4624941 | biostudies-literature
TranscriptomicsAGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline
The four mammalian Argonaute family members are thought to share redundant functions in the microRNA pathway, yet only AGO2 possesses the catalytic "slicer" function required for RNA interference. Whether AGO1, AGO3, or AGO4 possess specialized functions remains unclear. Here, we Series_su...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-39652 | biostudies-arrayexpress
UnknownSenataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing.
Not available
S-EPMC3623790 | biostudies-literature
UnknownEvaluating the relationship between spermatogenic silencing of the X chromosome and evolution of the Y chromosome in chimpanzee and human.
Not available
S-EPMC3001880 | biostudies-literature
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