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MetabolomicsPreliminary exploration of the ability of HUC-MSCs to restore the lung microbiota and related metabolite disorders in IPF treatment: Combining 16S sequencing and metabolite analysis

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive pulmonary disease, and effective therapies to reverse the natural course of IPF are lacking. A growing number of studies have shown that the use of human umbilical cord-derived mesenchymal stem cells (HUC-...

2025-09-01 | MTBLS12922 | MetaboLights
ProteomicsQuantitative protein profiling of conditioned medium cultured with various mesenchymal stem/stromal cells (MSCs)
To compare the proteins secreted by human primary cultured MSCs and human iPSC-derived MSCs in the medium, each MSCs and human dermal fibroblasts were cultured in PRIME-XV MSC Expansion XSFM medium for 48 hours, and the cultured media were collected. Albumin and immunoglobulin were removed from the ...
ORGANISM(S): Homo Sapiens (human) 
2022-09-29 | PXD035358 | JPOST Repository
TranscriptomicsTranscription profiling of human MSCs during expansion
Human mesenchymal stem cells or multipotent stromal cells (MSCs) are of interest for clinical therapy, in part because of their capacity for proliferation and differentiation. However, results from clinical trials and in vitro models have been variable, possibly due to MSC heterogeneity and a lack ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9520 | biostudies-arrayexpress
TranscriptomicsHomo sapiens MSCs: Normoxia vs. Hypoxia
Transcriptional profiling of human mesenchymal stem cells comparing normoxic MSCs cells with hypoxic MSCs cells. Hypoxia may inhibit senescence of MSCs during expansion. Goal was to determine the effects of hypoxia on global MSCs gene expression. Two-condition experiment, Normoxic MSCs vs. Hypoxic M...
ORGANISM(S): Homo sapiens 
2011-02-19 | E-GEOD-20463 | biostudies-arrayexpress
TranscriptomicsMesenchymal Stem Cells (MSCs): Control vs. PTH-stimulated
Transcriptional profiling of human MSCs comparing control MSCs with parathyroid hormone (PTH)-stimulated MSCs. PTH-stimulated MSCs were treated with 0.1 nM recombinant human PTH (N-terminal fragment, amino acids 1-34) for 48 hours. Human MSCs were isolated from a bone marrow sample obtained from a h...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-43148 | biostudies-arrayexpress
TranscriptomicsHomo sapiens immortalized MSCs: KP vs. 3A6
Gene methylation profiling of immortalized human mesenchymal stem cells comparing HPV E6/E7-transfected MSCs cells with human telomerase reverse transcriptase (hTERT)- and HPV E6/E7-transfected MSCs. hTERT may increase gene methylation in MSCs. Goal was to determine the effects of different transfec...
ORGANISM(S): Homo sapiens 
2011-08-24 | E-GEOD-23936 | biostudies-arrayexpress
TranscriptomicsExpression data from control and ZNF145-overexpressing human mesenchymal stem cells (MSCs)
ZNF145 is shown to be upregulated during three linage differentiation of MSCs especially in chondrogenesis. To understand the molecular basis of ZNF145 underlying MSCs, targets of ZNF145 in MSCs are determined by microarray We used microarrays to detail the change in gene expression profile upon ov...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-26272 | biostudies-arrayexpress
TranscriptomicsmiR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells
Administration of mesenchymal stem cells (MSCs) has the potential to ameliorate degenerative disorders and to repair damaged tissues. The homing of transplanted MSCs to injured sites is a critical property of engraftment. Our aim was to identify microRNAs involved in controlling MSC proliferation an...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-46989 | biostudies-arrayexpress
TranscriptomicsExpression data from human fetal cardiac MSCs
The instrinsic regenerative capacity of human fetal cardiac mesenchymal stromal cells (MSCs) has not been fully characterised. Here we demonstrate that we can expand cells with characteristics of cardiovascular progenitor cells from the MSC population of human fetal hearts with only minor fluctuatio...
ORGANISM(S): Homo sapiens 
2016-02-19 | E-GEOD-78047 | biostudies-arrayexpress
TranscriptomicsRegulation of Gene Expression by Connective Tissue Growth Factor (CTGF) in Mesenchymal Stromal Cells (MSCs)
mRNA from bone marrow-derived MSCs stably expressing CTGF-specific shRNA (or empty vector control) was analyzed for differential gene expression. Significant differences were found in cell proliferation-related genes, especially genes related to the M phase of the cell cycle, which were down-regulat...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-47575 | biostudies-arrayexpress
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