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TranscriptomicsThe MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila
Active genes on the X chromosome of Drosophila males are upregulated by the Male-specific lethal (MSL) complex containing five MSL proteins and two non-coding roX RNAs. To probe the targeting mechanism, we have solved the structure of the MSL3 chromodomain, designed point mutations in key residues t...
ORGANISM(S): Drosophila melanogaster 
2008-11-18 | E-GEOD-11817 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation to determine MSL1, MSL3, MOF and H4K16Ac binding in Drosophila SL2 and Kc cells reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila
Genome-wide binding profiles of MSL1, MSL3, MOF and H4K16Ac in Drosophila SL2 and Kc cells.
ORGANISM(S): Drosophila melanogaster 
2008-06-12 | E-MEXP-1508 | biostudies-arrayexpress
TranscriptomicsTiling path and RNAi of Drosophila KO MSL1, MLS3, and MOF reveals MOF as a key regulator of dosage compensation and gene expression
Effect of MSL1, MSL3 and MOF RNAi KOs in Drosophila SL-2 and Kc cells.
ORGANISM(S): Drosophila melanogaster 
2008-06-09 | E-MEXP-1505 | biostudies-arrayexpress
ProteomicsDe novo mutations of MSL3 cause a novel X-linked syndrome due to impaired histone H4 lysine 16 acetylation
Epigenetic regulation by histone acetylation plays a key role in cellular homeostasis and its misregulation is associated with human disease. Histone 4 Lysine 16 acetylation (H4K16ac) serves a unique role amongst the many histone modifications as it directly affects chromatin structure1. The Male Sp...
ORGANISM(S): Homo sapiens (Human) 
2018-09-18 | PXD009317 | Pride
X-linked syndrome Acetylation Histone h4 Msl3 Lysine 16 
GenomicsLoss Of Function of Male-Specific Lethal 3 (Msl3) Does Not Affect Spermatogenesis in Rodents
Loss Of Function of Male-Specific Lethal 3 (Msl3) Does Not Affect Spermatogenesis in Rodents
PRJNA987613 | ENA
UnknownMsl3 promotes germline stem cell differentiation in female Drosophila.
Not available
S-EPMC8783043 | biostudies-literature
UnknownCorecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Not available
S-EPMC2924628 | biostudies-literature
GenomicsMSL3 coordinates a transcriptional and translational meiotic program in female Drosophila
MSL3 coordinates a transcriptional and translational meiotic program in female Drosophila
PRJNA601455 | ENA
GenomicsLong range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X
Dosage compensation in D. melanogaster males is achieved via targeting of the MSL complex to X chromosomal genes. This is proposed to involve initial sequence-specific recognition of the X at ~150-300 chromatin entry sites, and subsequent spreading to nearby active genes. Here we test a model in whi...
ORGANISM(S): Drosophila melanogaster 
2009-08-20 | E-GEOD-17729 | biostudies-arrayexpress
TranscriptomicsLoss Of Function of Male-Specific Lethal 3 (Msl3) Does Not Affect Spermatogenesis in Rodents
Msl3 is a member of the chromatin-associated male-specific lethal MSL complex which is responsible for the transcriptional upregulation of genes on the X chromosome in males Drosophila. Although the dosage complex operates differently in mammals, the Msl3 gene is conserved from flies to humans. Msl3...
ORGANISM(S): Mus musculus 
2023-10-05 | GSE235777 | GEO
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