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GenomicsTranscriptome analysis of NOMO-1 cells with MSLN knockout
Transcriptome analysis of NOMO-1 cells with MSLN knockout
PRJNA1310324 | ENA
ProteomicsProtein mass spectrometry raw data of M7A, M7GA, M7A-DC, and M7GA-DC for DAR calculation in study of MSLN-directed DARPin-drug conjugates
Mesothelin (MSLN) is an attractive therapeutic target for precision cancer treatments. Here, we identify a MSLN-targeting DARPin, M7, which specifically binds to the protease-sensitive C-terminal region of MSLN. Furthermore, we develop two auristatin-based DARPin-drug conjugates (DARPin-DCs), M7A-DC...
ORGANISM(S): Escherichia coli 
2025-09-05 | PXD065630 | Pride
Lc/ms Protein-drug conjugates 
TranscriptomicsTranscriptome analysis of NOMO-1 cells with MSLN knockout
MSLN is a newly identified AML target. Because MSLN is not expressed in normal bone marrow specimens, it is an attractive immunotherapy target. However, the function of MSLN in AML is unknown. We generated NOMO-1 cells with CRISPR/CAS9 knockout and performed transcriptome analysis to understand the ...
ORGANISM(S): Homo sapiens 
2026-05-15 | GSE306271 | GEO
UnknownTransplantation of the MSLN-deficient Thymus Generates MSLN Epitope Reactive T Cells to Attenuate Tumor Progression.
Not available
S-EPMC11967271 | biostudies-literature
GenomicsIdentifying new signaling mediators responsible for Mesothelin (MSLN) intraperitoneal (IP) tumor growth phenotype
Identifying new signaling mediators responsible for Mesothelin (MSLN) intraperitoneal (IP) tumor growth phenotype
PRJNA544323 | ENA
ProteomicsHighly Active CAR T Cells that Bind to a Juxta-Membrane Region of Mesothelin and are Not Blocked by Shed Mesothelin
Identification of the major protease sites in MSLN and preparation of a monoclonal antibody, 15B6, that binds next to cell membrane at the protease sensitive region and inhibits MSLN shedding. Mab 15B6 makes very active CAR-T cells whose activity is not blocked by shed MSLN. The 15B6 CAR-T cells hav...
ORGANISM(S): Homo sapiens (Human) 
2022-04-13 | PXD033137 | Pride
Cancer Antibody Ovarian cancer Immunotherapy Pancreatic cancer 
TranscriptomicsIdentifying new signaling mediators responsible for Mesothelin (MSLN) intraperitoneal (IP) tumor growth phenotype
Identification of new targets involved in MSLN signaling by comparing mRNA expression patterns in MSLN WT and KO in both cells grown in culture and in IP tumor tissues using RNA deep sequencing
ORGANISM(S): Homo sapiens 
2020-05-23 | GSE131664 | GEO
GenomicsMSLN-mediated activation of EGFR-ERK1/2 signaling drives liver metastasis in breast cancer [HCC1806-HM3]
MSLN-mediated activation of EGFR-ERK1/2 signaling drives liver metastasis in breast cancer [HCC1806-HM3]
PRJNA1309494 | ENA
UnknownTrogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality.
Not available
S-EPMC9313125 | biostudies-literature
UnknownMicroenvironmental alkalization promotes the therapeutic effects of MSLN-CAR-T cells.
Not available
S-EPMC11499857 | biostudies-literature
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