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TranscriptomicsExpression data from Mst knockout embryoid bodies and wild type embryoid bodies
Mst1/Mst2 are central components of Hippo pathway. We examined the role of Mst1/Mst2 in ES cell differentiation. In this data set, we include expression data from day 4 and day 8 Mst1/Mst2 knockout ES cell formed embryoid bodies and wild type embryoid body controls. total 4 samples.
ORGANISM(S): Mus musculus 
2014-01-02 | E-GEOD-50219 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of Mst1/2 deleted bronchiolar epithelial cells from adult mouse lungs
Mst1 and Mst2 were conditionally deleted from non-ciliated bronchiolar epithelial cells in the mature lung. Bronchiolar epithelial cells from control and Mst1/2 deleted mice were isolated by cell sorting and used for RNA-seq analysis. Scgb1a1-rtTA/tetO-Cre/Mst1;2-flx/flx (Mst1/2 D/D) mice were gene...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-61627 | biostudies-arrayexpress
TranscriptomicsGene profiling of heart atria in PI3K and Mst1 mouse models
We used microarrays to detail genome-wide gene expression underlying cardiac myocyte pathologies and identified candidate genes and specific pathways affecting cardiac myopathies Keywords: transgenics, cardiac disease analysis Mouse heart atria were dissected for RNA extraction and hybridisation on...
ORGANISM(S): Mus musculus 
2010-04-07 | E-GEOD-12420 | biostudies-arrayexpress
TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
TranscriptomicsMicroarray of Mst1/2 deleted epithelial cells from E18.5 mouse lungs
ShhCre;Mst1/2flx/flx (Mst1/2 D/D) mice were generated to conditionally delete Mst1 and Mst2 from epithelial progenitors during lung morphogenesis. Lungs from E18.5 control and Mst1/2 D/D mice were mechanically and enzymatically dissociated to generate single cell suspension. Epcam(+) cells were is...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-61582 | biostudies-arrayexpress
GenomicsPaenibacillus tyrphae strain:MSt1
Paenibacillus tyrphae strain:MSt1 Genome sequencing and assembly
PRJNA246682 | ENA
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type, Mst1/2 dKO and Mst1/2 Yap tKO Initial segments of Epididymis Transcriptomes
Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type, Mst1/2 dKO and Mst1/2 Yap tKO Initial segments of Epididymis Transcriptomes
PRJNA576235 | ENA
TranscriptomicsGene expression profile of mouse liver cancer (Sav1 and Mst1/2 Knockout models)
Hippo pathway is evolutionarily well conserved. All core components of the pathway identified to date have one or more mammalian orthologs, including MST1/2 (Hippo), SAV1 (Salvador, also known as WW45), LATS1/2 (Warts), MOB1 (Mats), YAP1 and its paralog WWTR1 (also known as TAZ) (Yorkie), and TEAD1/...
ORGANISM(S): Mus musculus 
2014-08-23 | E-GEOD-32510 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of effect of Yap inhibition in a genetically engineered mouse model of hepatocellular carcinoma
Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. We show that YAP functions as a rheostat maintaining metabolic specialization, differe...
ORGANISM(S): Mus musculus 
2015-03-07 | E-GEOD-65665 | biostudies-arrayexpress
GenomicsTranscriptional profiling of MST1 or FOXO1 depleted human umbilical vein endothelial cells
Transcriptional profiling of MST1 or FOXO1 depleted human umbilical vein endothelial cells
PRJNA476865 | ENA
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