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GenomicsAeromonas sp. MTB isolate:MTB
Aeromonas sp. MTB isolate:MTB Genome sequencing and assembly
PRJNA1083721 | ENA
TranscriptomicsPDE-4 inhibition alters gene expression and improves INH-mediated clearance of Mtb in rabbit lungs
Tuberculosis kills nearly 2 million people through out the world, every year. The outcome of M. tuberculosis infection is determined by the host and bacterial factors. A strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response,...
ORGANISM(S): Oryctolagus cuniculus 
2011-03-16 | E-GEOD-27992 | biostudies-arrayexpress
MetabolomicsMultiplatform, non-targeted analysis of lung extracts of uninfected and Mtb-infected C57BL/6 mice at 4 and 9 weeks p.i.
Not available
ORGANISM(S): Mus musculus 
ST001328 | MetabolomicsWorkbench
TranscriptomicsMycobacterium tuberculosis whiB4 mutant expression
Comparison of gene expression profile of the whiB4 mutant strain of Mycobacterium tuberculosis with the wild type Mycobacterium tuberculosis H37RV Mtb WhiB4 mutant mRNA was compared with the mRNA of wtMtb H37RV under aerobic conditons Aerbic conditions OD600 nm of 0.4, MtbWhiB4KO vs wtMtb, biologica...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2012-07-23 | E-GEOD-37840 | biostudies-arrayexpress
TranscriptomicsA Novel Gene Regulates Vesiculogenesis and Immunomodulation in Mycobacterium tuberculosis
After co-evolving with humans, its only major host, Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication, yet elicits enough immunopathology to ensure its transmission. Here, we provide evidence that this balance is regulated in part by a previously uncharact...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-50050 | biostudies-arrayexpress
GenomicsMycobacterium tuberculosis strain:Mtb
Mycobacterium tuberculosis strain:Mtb Genome sequencing and assembly
PRJNA638161 | ENA
TranscriptomicsThe Mycobacterium tuberculosis Clp Gene Regulator is Required for in vitro Reactivation from Hypoxia-induced Dormancy
The isogenic Mtb:ΔRv2745c mutant is significantly more sensitive normoxia conditions after a period of hypoxia, relative to wild-type Mtb, implicating a role for ClgR in response to reactivation, in vivo. Both hypoxia and reaeration treatment led to dysregulation of the σH regulon in the isogenic mu...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2014-12-12 | E-GEOD-64065 | biostudies-arrayexpress
TranscriptomicsThe Mycobacterium tuberculosis Rv2745c Plays an Important Role in Responding to Redox Stress
The Rv2745c (clgR) gene encodes a Clp protease gene regulator that is induced in response to a variety of stress conditions and potentially plays a role in Mtb pathogenesis. The isogenic Mtb:ΔRv2745c mutant is significantly more sensitive to in vitro redox stress generated by diamide, relative to wi...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2014-03-25 | E-GEOD-55817 | biostudies-arrayexpress
TranscriptomicsmiRNA profile of THP-1 macrophage infected with different MTB strains
We examined the microRNA profiles of THP-1 macrophages upon the MTB infection of (1) Beijing/W and non-Beijing/W clinical strains, and (2) susceptible and multidrug-resistant (MDR-) MTB strains. THP-1 cells were induced differentiation into a macrophage phenotype. Then cells were infected with three...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-65811 | biostudies-arrayexpress
TranscriptomicsM. tuberculosis (Mtb) Produces Nitrite in Human Macrophages in Physiologic Oxygen to Impact Mycobacterial ATP Consumption and Gene Expression
We sequenced mRNA from Mtb that had been treated with 5 mM nitrate or was untreated in standard 7H9/ADNaCl medium. This generated the first analysis of gene expression following mycobacterial nitrate respiration. Examination of mRNA levels in Mtb following nitrate respiration, which results in the p...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-10-21 | E-GEOD-51037 | biostudies-arrayexpress
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