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MetabolomicsUntargeted lipid profiling following mTOR inhibition

The mechanistic target of rapamycin (mTOR) is pivotal in programming cellular lipid homeostasis for the structural and functional integrity of cells. Dysregulation of mTOR and consequent altered lipid metabolism are common features in various diseases, including cancers, making mTOR signaling a p...

2025-09-20 | MTBLS12837 | MetaboLights
MetabolomicsSelective mTOR inhibition via FLCN drives TFE3-dependent VLDL-TG secretion and protects from MAFLD/MASH
Hepatic lipid homeostasis is controlled by multiple processes, including VLDL-TG secretion. We have previously shown that the FLCN/TFE3 branch of mTORC1 signaling controls hepatic fatty acid oxidation and de novo lipogenesis to protect mice from MAFLD. We now show that the FLCN/TFE3 pathway also con...
2026-09-08 | MTBLS15598 | MetaboLights
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsProteomic profiling of colorectal cancer cell culture samples treated with apoptosis- and mTOR inhibitors under normoxia and hypoxia
To examine changes in tyrosine kinase activity in colorectal cancer cell culture samples treated with apoptosis inhibitors or/and mTOR inhibitors, under normoxic or/and hypoxic experimental conditions.
ORGANISM(S): Homo sapiens 
2016-06-15 | E-MTAB-3870 | biostudies-arrayexpress
MetabolomicsSchisandra chinensis alleviates dextran sulfate sodium-induced colitis in association with remodeling of a Parabacteroides goldsteinii-related leucine– isovalerate metabolic axis and attenuation of mTOR/HIF-1α/IL-17 signaling

Ulcerative colitis (UC) involves epithelial injury, gut microbial dysbiosis, disturbed microbial metabolism, and mucosal inflammation. This study evaluated the protective effect of Schisandra chinensis (SC) against dextran sulfate sodium (DSS)-induced UC and investigated the underlying microbiota...

2026-08-29 | MTBLS15496 | MetaboLights
TranscriptomicsThe translational landscape of mTOR signaling steers cancer initiation and metastasis
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer development are poorly characterized. Employing riboso...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35469 | biostudies-arrayexpress
TranscriptomicsThe TSC/mTOR pathway regulates the innate inflammatory response
The TSC/mTOR (tuberous sclerosis complex/mammalian target of rapamycin) pathway has a central role in cell growth and is involved in human tumorigenesis. Here, we demonstrate an unexpected role of TSC2 and mTOR in regulating key inflammatory cytokines in monocytes, macrophages, and dendritic cells a...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-6002 | biostudies-arrayexpress
TranscriptomicsTLR-mediated type I IFN induction in pDCs requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway
Robust type I interferon (IFN-alpha/beta) production in plasmacytoid dendritic cells (pDCs) is critical for anti-viral immunity. Here we demonstrated a role for the mammalian target of rapamycin (mTOR) pathway in regulating interferon production by pDCs. Inhibition of mTOR or the ‘downstream’ mediat...
ORGANISM(S): Mus musculus 
2008-12-01 | E-GEOD-12218 | biostudies-arrayexpress
TranscriptomicsSomatic Gain-of-Function mTOR mutation in Clonally Expanded T-lymphocytes Associated with Chronic Graft-Versus-Host Disease
Graft-versus-host-disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient with chronic GVHD (cGVHD) carrying persistent CD4+ T cell clonal expansion which harbored somatic mTOR, NFKB2, and TLR2 mutations. Functional an...
ORGANISM(S): Homo sapiens 
2020-04-12 | E-MTAB-8911 | biostudies-arrayexpress
TranscriptomicsResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
We explored potential bypass mechanisms to PI3K/mTOR-directed therapy in KRAS mutant CRC models, utilizing genetically engineered mouse models (GEMM) to generate acquired resistance to the targeted dual PI3K/mTOR small molecule inhibitor PF-04691502. Transcriptomic analysis revealed a dynamic stem-l...
ORGANISM(S): Mus musculus 
2014-08-31 | E-MTAB-2510 | biostudies-arrayexpress
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