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MetabolomicsDEGS1-mTORC1-driven lipid metabolic reprogramming fuels rhabdomyosarcoma progression and unveils a therapeutic vulnerability
These findings establish a mechanistic link between sphingolipid metabolism, mTORC1-mediated regulation of lipophagy, and tumor aggressiveness, highlighting lipid droplet metabolism as a novel and tractable therapeutic target in RMS.
2026-10-02 | MTBLS15896 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
MetabolomicsSARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
Not available
ORGANISM(S): Homo sapiens 
ST001709 | MetabolomicsWorkbench
UnknownCotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC.
Not available
S-EPMC5505754 | biostudies-literature
TranscriptomicsmTORC inhibition of neuroblastoma SK-N-BE(2)c cells cultured under hypoxic conditions
Differential expression of the oxygen sensitive hypoxia-inducible transcription factor (HIF) subunits HIF-1a and HIF-2a occurs in many tumor types, but the underlying regulatory mechanisms remain poorly understood. Here we investigate the role of mTOR complex in the regulation of HIF expression in c...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-69833 | biostudies-arrayexpress
UnknownSoluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy.
Not available
S-EPMC8068623 | biostudies-literature
UnknownSynthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors.
Not available
S-EPMC9648566 | biostudies-literature
UnknownmTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action.
Not available
S-EPMC2832937 | biostudies-literature
GenomicsClonal diversity of mTORC high and low AML before and after chemotherapy
Clonal diversity of mTORC high and low AML before and after chemotherapy
PRJNA680765 | ENA
UnknownTherapeutic Mechanisms of Berberine to Improve the Intestinal Barrier Function via Modulating Gut Microbiota, TLR4/NF-κ B/MTORC Pathway and Autophagy in Cats.
Not available
S-EPMC9354406 | biostudies-literature
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