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MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
UnknownCotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC.
Not available
S-EPMC5505754 | biostudies-literature
UnknownSoluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy.
Not available
S-EPMC8068623 | biostudies-literature
TranscriptomicsmTORC inhibition of neuroblastoma SK-N-BE(2)c cells cultured under hypoxic conditions
Differential expression of the oxygen sensitive hypoxia-inducible transcription factor (HIF) subunits HIF-1a and HIF-2a occurs in many tumor types, but the underlying regulatory mechanisms remain poorly understood. Here we investigate the role of mTOR complex in the regulation of HIF expression in c...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-69833 | biostudies-arrayexpress
UnknownSynthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors.
Not available
S-EPMC9648566 | biostudies-literature
UnknownmTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action.
Not available
S-EPMC2832937 | biostudies-literature
UnknownMechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species.
Not available
S-EPMC6512105 | biostudies-literature
UnknownTherapeutic Mechanisms of Berberine to Improve the Intestinal Barrier Function via Modulating Gut Microbiota, TLR4/NF-κ B/MTORC Pathway and Autophagy in Cats.
Not available
S-EPMC9354406 | biostudies-literature
UnknownAcute Conditioning of Antigen-Expanded CD8+ T Cells via the GSK3β-mTORC Axis Differentially Dictates Their Immediate and Distal Responses after Antigen Rechallenge.
Not available
S-EPMC7765077 | biostudies-literature
UnknownTBCK influences cell proliferation, cell size and mTOR signaling pathway.
Not available
S-EPMC3747267 | biostudies-literature
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