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UnknownMitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.
Not available
S-EPMC6468249 | biostudies-literature
UnknownAlkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).
Not available
S-EPMC3998512 | biostudies-literature
ProteomicsThe mitochondrial single-stranded DNA binding protein directs RNA primer formation for mtDNA replication
Single-stranded DNA (ssDNA) binding proteins protect regions of ssDNA formed during processes such as DNA replication and repair. We here devise a genetic screen and identify the mitochondrial ssDNA-binding protein (mtSSB) as a key regulator of mtDNA levels. In mitochondria, RNA synthesis from the l...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-19 | PXD021799 | Pride
Mtdna Tmt Replication Mtssb 
UnknownLoss of mitochondrial single stranded DNA-binding protein (mtSSB) gene is associated with mitochondrial genome fragmentation in Psocodea (bark lice, book lice, and parasitic lice).
Not available
S-EPMC12797587 | biostudies-literature
UnknownReduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells.
Not available
S-EPMC3220507 | biostudies-literature
TranscriptomicsThe mitochondrial single-stranded DNA binding protein directs RNA primer formation for mtDNA replication [sRNA]
Single-stranded DNA (ssDNA) binding proteins protect regions of ssDNA formed during processes such as DNA replication and repair. We here devise a genetic screen and identify the mitochondrial ssDNA-binding protein (mtSSB) as a key regulator of mtDNA levels. In mitochondria, RNA synthesis from the l...
ORGANISM(S): Mus musculus 
2021-07-06 | GSE159570 | GEO
TranscriptomicsThe mitochondrial single-stranded DNA binding protein directs RNA primer formation for mtDNA replication [TruSeq]
Single-stranded DNA (ssDNA) binding proteins protect regions of ssDNA formed during processes such as DNA replication and repair. We here devise a genetic screen and identify the mitochondrial ssDNA-binding protein (mtSSB) as a key regulator of mtDNA levels. In mitochondria, RNA synthesis from the l...
ORGANISM(S): Mus musculus 
2021-07-06 | GSE159569 | GEO
TranscriptomicsThe mitochondrial single-stranded DNA binding protein directs RNA primer formation for mtDNA replication
Single-stranded DNA (ssDNA) binding proteins protect regions of ssDNA formed during processes such as DNA replication and repair. We here devise a genetic screen and identify the mitochondrial ssDNA-binding protein (mtSSB) as a key regulator of mtDNA levels. In mitochondria, RNA synthesis from the l...
ORGANISM(S): Homo sapiens Mus musculus 
2022-08-29 | GSE159481 | GEO
UnknownSingle-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein.
Not available
S-EPMC6265486 | biostudies-literature
UnknownThe human mitochondrial single-stranded DNA-binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange.
Not available
S-EPMC5546044 | biostudies-literature
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