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MetabolomicsDistinct metabolic responses of an ovarian cancer stem cell line

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the leve...
2021-11-05 | MTBLS150 | MetaboLights
MetabolomicsMetabolomics identifies the intersection of phosphoethanolamine with menaquinone- triggered apoptosis in an in vitro model of leukemia
Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells led to preliminary evidence ...
2015-10-19 | MTBLS226 | MetaboLights
TranscriptomicsMu killer-mediated and spontaneous silencing of Zea mays Mutator family transposable elements define distinctive paths of epigenetic inactivation
Mu killer contains a partial inverted duplication of the mudrA transposase gene and two copies of the terminal inverted repeat A region of MuDR. Mu killer can effectively silence single copy MuDR/Mu lines but failed to silence about 25% of the time in multiple copy lines. Mu killer was partially seq...
ORGANISM(S): Zea mays 
2012-07-27 | E-GEOD-38314 | biostudies-arrayexpress
MetabolomicsGermacrone Protects Against DSS Induced Colitis Through a Gut Microbiota Derived Indole-3-Carboxylic Acid-AhR-ILC3/IL-22 Axis
Ulcerative colitis (UC) is a chronic recurrent inflammatory bowel disease, which is characterized by intestinal microbiota dysbiosis, intestinal barrier and mucosal immune dysfunction. Given the limited effect of biological agents for UC, there is an urgent need to develop more effective pharmacolog...
2026-08-30 | MTBLS15475 | MetaboLights
MetabolomicsRegulatory actors and alternative routes for Arabidopsis seed germination are revealed using a pathway‐based analysis of transcriptomic datasets
Regulation of seed germination by dormancy relies on a complex network of transcriptional and post‐transcriptional modifications during seed imbibition that controls seed adaptive responses to environmental cues. High‐throughput technologies have brought significant progress in the understanding of ...
2019-05-21 | MTBLS662 | MetaboLights
UnknownA μ-Phosphido Diiron Dumbbell in Multiple Oxidation States.
Not available
S-EPMC6790664 | biostudies-literature
UnknownExperience: developing an inpatient malnutrition checklist for children 6 to 59 months to improve WHO protocol adherence and facilitate quality improvement in a low-resource setting.
Not available
S-EPMC6097458 | biostudies-literature
Transcriptomicsde novo childhood AML patients and FLT3 mutations.
This data set was used to study FLT3 wild type and mutants in childhood AML samples from the Pediatric Oncology Group Study 9421. Abstract: Fms-like tyrosine kinase 3 (FLT3) mutations are associated with unfavorable outcomes in children with acute myeloid leukemia (AML). We used DNA microarrays to i...
ORGANISM(S): Homo sapiens 
2006-01-06 | E-GEOD-3986 | biostudies-arrayexpress
ProteomicsAntagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling
The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for the MDOR in vivo is indirect and limited,...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD022106 | Pride
Opiod mdor oxymorphone nociception 
ProteomicsProfiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors
G protein-coupled receptors (GPCRs) regulate many aspects of physiology and represent actionable targets for drug discovery. Activation of specific signaling pathways downstream of G-protein coupled receptors (GPCRs) or targeting the receptors at selected cellular locations has the potential to prov...
ORGANISM(S): Homo sapiens (Human) 
2024-03-30 | PXD031415 | Pride
Ap-ms Mu opioid receptor Dia Apex Gpcr Dda 
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