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UnknownA New Method for Abrin Detection Based on the Interaction between Target Molecules and Fluorescently Labeled Aptamers on Magnetic Microspheres.
Not available
S-EPMC9573059 | biostudies-literature
GenomicsGenome-wide maps of Tbx3 binding sites in mouse ESCs
Induced pluripotent stem (iPS) cells can be obtained through the introduction of defined factors into somatic cells. The combination of Oct4, Sox2 and Klf4 (OSK) constitutes the minimal requirement for generating iPS cells from mouse embryonic fibroblasts (MEFs). Through the genomic analyses of ESC ...
ORGANISM(S): Mus musculus 
2009-12-04 | E-GEOD-19219 | biostudies-arrayexpress
TranscriptomicsMicroarray-based CGH in human cancer cell lines
This series represents the data set from the paper Assembly of microarrays for genome-wide measurement of DNA copy number appearing in Nat Genet 2001 Nov;29(3):263-4 and it's web supplement. Specimen procurement, labeling, hybridization and imaging protocols from Nat Genet 2001 Nov;29(3):263-...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-16 | biostudies-arrayexpress
TranscriptomicsComplete Haplotype Phasing of the MHC and KIR Loci with Targeted HaploSeq
Rapid advances in biochemical technologies have enabled several strategies for typing candidate HLA alleles, but linking them into a single MHC haplotype structure remains challenging. Here we have developed a multi-loci haplotype phasing technique and demonstrate its utility towards phasing of MHC ...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-GEOD-65726 | biostudies-arrayexpress
TranscriptomicsATF4 governs functional expansion of hematopoietic stem cells partially via Angptl3 in the fetal liver microenvironment (RNA-Seq)
In this study, we demonstrated that deletion of the activating transcription factor 4 (ATF4) resulted in severely impaired HSC expansion in the fetal liver at E12.5 and E15.5. In contrast, generation of the first HSC population in the aorta-gonad-mesonephros region at E11.5 was not significantly aff...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-66380 | biostudies-arrayexpress
TranscriptomicsATF4 governs functional expansion of hematopoietic stem cells partially via Angptl3 in the fetal liver microenvironment (array)
In this study, we demonstrated that deletion of the activating transcription factor 4 (ATF4) resulted in severely impaired HSC expansion in the fetal liver at E12.5 and E15.5. In contrast, generation of the first HSC population in the aorta-gonad-mesonephros region at E11.5 was not significantly aff...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-66381 | biostudies-arrayexpress
GenomicsCBX3 Regulates Efficient RNA Processing Genome Wide
HP1 alpha, beta, and gamma play an evolutionarily conserved role in the formation and maintenance of heterochromatin. In addition, some HP1 family members may also participate in transcriptional regulation of genes. Recently, HP1 gamma binding to the bodies of a subset of genes has been observed in ...
ORGANISM(S): Homo sapiens 
2012-05-24 | E-GEOD-28115 | biostudies-arrayexpress
TranscriptomicsInteractive effects of arsenic and a high-fat diet on hepatic gene expression
Chronic exposure to inorganic arsenic (iAs) or a high-fat diet (HFD) can produce liver injury. However, the interactive molecular biological effects and mechanism of iAs and HFD are as of yet unclear. We used microarrays to detail the interactive effects of arsenic and a high-fat diet on hepatic gen...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-52702 | biostudies-arrayexpress
GenomicsEnvironmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus
Gene-environment interactions mediated at the epigenetic level may provide an initial step in delivering an appropriate response to environmental changes. 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC), accounts for ~40% of modified cytosine in brain and has been impl...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-61194 | biostudies-arrayexpress
GenomicsGraded Nodal/Activin Signaling Governs ES Cell Fate Decisions via Differential Recruitment of Phospho-Smad2 to Oct4 and Distinct Target Gene Subsets.
The Nodal/Activin morphogens are secreted signaling molecules that form concentration gradients during early embryogenesis providing stem cells with positional information and differentiation instructions important for embryonic patterning. The molecular basis driving stem cell interpretation of sig...
ORGANISM(S): Mus musculus 
2011-01-31 | E-GEOD-23581 | biostudies-arrayexpress
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