Sort   by:  
 Page size 
ProteomicsCardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 to inhibit AMPK activity and induce mitochondrial dysfunctionCardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 to inhibit AMPK activity and induce mitochondrial dysfunction
The sample was removed from-80℃ and melted on ice. An appropriate amount of TEAB was added to adjust pH 8.0.5 μ L of suspension was used for SDS-PAGE testing.
ORGANISM(S): Homo sapiens (Human) 
2025-06-11 | PXD061479 | Pride
Human，cells，lc-msms 
TranscriptomicsTranscription profiling of aortic media from L-NAME and atorvastatin treated male rats
One-month-old male Fischer 344 rats with an initial body weight of 150 g were used for this study and were divided into 7 groups: a control group (30 days), 2 groups intoxicated with L-NAME (50 mg/kg per day in the drinking water; Sigma Chemical Co) for 15 and 30 days, 2 groups treated with atorvast...
ORGANISM(S): Rattus norvegicus 
2006-12-31 | E-MEXP-33 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis LEC1-overexpressing transgenic plants reveals LEAFY COTYLEDON1 is a key regulator of fatty acid biosynthesis in Arabidopsis thaliana
In plants, fatty acids are de novo synthesized predominantly in plastids fromacetyl-CoA. Although fatty acid biosynthesis has been biochemically well-studied, little isknown about the regulatory mechanisms of the pathway. Here, we show that overexpressionof the Arabidopsis (Arabidopsis thaliana) LEA...
ORGANISM(S): Arabidopsis thaliana 
2008-10-25 | E-GEOD-12137 | biostudies-arrayexpress
TranscriptomicsSystems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase
Background: The biotechnology industry has extensively exploited Escherichia coli for producing recombinant proteins, biofuels etc. However, high growth rate aerobic E. coli cultivations are accompanied by acetate excretion i.e. overflow metabolism which is harmful as it inhibits growth, diverts val...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2010-09-02 | E-GEOD-23920 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish livers following exposure to 17 alpha-ethynylestradiol (EE2) at 0, 15, 40, or 100 ng/L
Genomic, proteomic, and metabolomic technologies continue to receive increasing interest from environmental toxicologists. This interest is due to the great potential of these technologies to identify detailed modes of action and to provide assistance in the evaluation of a contaminant?s risk to aq...
ORGANISM(S): Danio rerio 
2007-02-24 | E-TABM-105 | biostudies-arrayexpress
UnknownAssociation between serum unsaturated fatty acids levels and infertility among American women from the National Health and Nutrition Examination Survey 2013-2014.
Not available
S-EPMC11566495 | biostudies-literature
TranscriptomicsSingle cell RNA-seq of Panc02-H7-Fluc model with vehicle tobemstomig, nivolumab and relatlimab-like treatment
We used transgenic mice challenged subcutaneously with Panc02-H7-Fluc tumors to compare the efficacy of tobemstomig with nivolumab and relatlimab-like monotherapies, as well as their combination, and further investigated their mechanism of action. We used a murinized version of tobemstomig, nivoluma...
ORGANISM(S): Mus musculus 
2025-11-27 | E-MTAB-15144 | biostudies-arrayexpress
TranscriptomicsMycorrhizal Metabolome: L. bicolor :: P. trichocapra
Mycorrhizae, symbiotic interactions between soil fungi and tree roots, are ubiquitous in terrestrial ecosystems. The fungi contribute phosphorous, nitrogen and mobilized nutrients from organic matter in the soil and in return the fungus receives photosynthetically-derived carbohydrates. This union...
ORGANISM(S): Populus tremuloides 
2011-03-25 | E-GEOD-28157 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of transporters, phytohormone and lipid metabolism pathways in response to arsenic stress in rice (Oryza Sativa L.)
Arsenic (As) is a carcinogenic metalloid that is a contaminant widely polluting rice paddy soils around the world. In order to gain better insight into molecular mechanism of rice exposed to As(III) stress, we used next-generation sequencing technology to acquire global transcriptome alteration and ...
ORGANISM(S): Oryza sativa Japonica Group 
2013-01-09 | E-GEOD-36696 | biostudies-arrayexpress
GenomicsPrep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
Prep1 is a tumor-suppressor, whereas Meis1 is an oncogene. We show that to perform these activities in MEFs both proteins competitively hetero-dimerize with Pbx1. Meis1 alone transforms Prep1-deficient fibroblasts while Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can therefore alternati...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-54221 | biostudies-arrayexpress
Sort   by:  
 Page size