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MetabolomicsJejunal inflammatory cytokines, barrier proteins and microbiome-metabolome responses to early supplementary feeding of Bamei suckling piglets

BACKGROUND: Dietary intervention has been reported to improve intestinal health. The intestinal microbiota of newborn animals plays a fundamental role in the development of intestinal function and the innate immune system. However, little is currently known about dietary interven...

2020-06-05 | MTBLS1698 | MetaboLights
MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
MetabolomicsDual Effects of Fasting on Gut Microbiota and Metabolism: Protective Adaptation versus Barrier Dysfunction Risks
Fasting is increasingly recognized as a metabolic intervention that reshapes gut microbiota and host metabolism, but its duration-dependent effects on intestinal epithelial integrity remain incompletely understood. In this study, we compared ad libitum feeding, 12 h fasting, and 24 h fasting in male...
2026-07-20 | MTBLS15098 | MetaboLights
MetabolomicsQijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB Pathway

Background: Qijiao Shengbai capsule (QJSB) is a classic traditional Chinese compound formulation composed of seven herbal ingredients, primarily used clinically to treat leukopenia. Individual herbs and their active components within QJSB demonstrate favorable efficacy against ulcerative colitis ...

2026-09-08 | MTBLS14941 | MetaboLights
MetabolomicsQijiao Shengbai capsule ameliorates ulcerative colitis in mice by modulating gut microbiota and protecting the intestinal barrier, associated with suppression of the TLR4/MyD88/NF-κB Pathway

Background: Qijiao Shengbai capsule (QJSB) is a classic traditional Chinese compound formulation composed of seven herbal ingredients, primarily used clinically to treat leukopenia. Individual herbs and their active components within QJSB demonstrate favorable efficacy against ulcerative colitis ...

2026-09-08 | MTBLS14943 | MetaboLights
TranscriptomicsDifferential Targeting of the E-Cadherin and b-Catenin Complex by Gram-positive Probiotic Lactobacilli Improves Epithelial Barrier Function
The intestinal ecosystem is balanced by dynamic interactions between resident and incoming microbes, the gastrointestinal barrier, and the mucosal immune system. However, in the context of inflammatory bowel diseases (IBD) where the integrity of the gastrointestinal barrier is compromised, resident ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-MEXP-3445 | biostudies-arrayexpress
UnknownThe Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair.
Not available
S-EPMC8605999 | biostudies-literature
UnknownPotential Roles of Exosomal lncRNAs in the Intestinal Mucosal Immune Barrier.
Not available
S-EPMC8413039 | biostudies-literature
GenomicsEnteric Nervous System Derived IL-18 Orchestrates Mucosal Barrier Immunity [DropSeq]
Enteric Nervous System Derived IL-18 Orchestrates Mucosal Barrier Immunity [DropSeq]
PRJNA594860 | ENA
GenomicsDietary Inulin Enhances Mucosal Immune Responses In Helminth-Infected Pigs
Mucosal Barrier and Th2 Immune Responses are Enhanced by Dietary Inulin in Pigs Infected with Trichuris suis
PRJEB29079 | ENA
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