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TranscriptomicsArrays of time course experiment (2-28 d) laser microdissected samples of H. pylori -infected mice
Mice were infected with Helicobacter pylori strain SS1 for 2, 7, 14 or 28 days or left uninfected. They were sacrificed at the appropriate times, the stomachs were removed and one half was plated for colony counts. The other half was embedded in OCT and cryosections were produced for 6-7 animals per...
ORGANISM(S): Mus musculus 
2012-05-11 | E-GEOD-37938 | biostudies-arrayexpress
TranscriptomicsHistopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma.
Long-term colonization of humans with Helicobacter pylori can cause the development of gastric B cell mucosa-associated lymphoid tissue lymphoma, yet little is known about the sequence of molecular steps that accompany disease progression. We used microarray analysis and laser microdissection to ide...
ORGANISM(S): Mus musculus 
2005-11-22 | E-GEOD-3648 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array in rat of age-dependent gene expression in sensorimotor cortex following spinal cord injury
In this study, we investigated the extent and nature of the difference between the dynamic cortical gene expression profiles of aged (22-month-old) and young (2-month-old) rats following thoracic corticospinal tract (CST) transection and whether the anti-scarring-treatment (AST)-induced regeneration...
ORGANISM(S): Rattus norvegicus 
2012-01-15 | E-MTAB-794 | biostudies-arrayexpress
TranscriptomicsRole of antigenic drive in pathogenesis of MALT lymphoma
In order to assess the effect that eradication therapy and re-infection have on colonization densities and histopathology of BALB/c mice, 35 mice were divided into four groups (A-D): 12 mice were infected for the duration of the experiment (23 months, primarily infected group B), 8 mice were infecte...
ORGANISM(S): Mus musculus 
2005-08-31 | E-GEOD-3237 | biostudies-arrayexpress
TranscriptomicsResponse of Staphylococcus aureus to subinhibitory concentrations of a sequence-selective, DNA minor groove cross-linking pyrrolobenzodiazepine dimer.
Objectives ELB-21 is a pyrrolo[2,1-c][1,4]benzodiazepine dimer with potent antistaphylococcal activity; it binds covalently to guanine residues on opposing strands of duplex DNA, interfering with regulatory proteins and transcription elongation in a sequence-selective manner. Transcriptional and pro...
ORGANISM(S): Staphylococcus aureus 
2009-09-18 | E-BUGS-79 | biostudies-arrayexpress
TranscriptomicsScreening for chromosomal aberrations by array CGH in 74 patients with congenital hypothyroidism
Congenital Hypothyroidism occurs in 1:3500 live births and is therefore the most common congenital endocrine disorder. A spectrum of defective thyroid morphology, termed thyroid dysgenesis, represents 80% of permanent CH cases. Although several candidate genes have been implicated in thyroid develop...
ORGANISM(S): Homo sapiens 
2010-05-31 | E-GEOD-18152 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile of human MALT lymphoma compared to gastritis and gDLBCL
To obtain global miRNA expression signatures of gDLBCL and its precursor lesions, total RNA isolated from 7-8 cases each of Helicobacter-associated reactive gastritis, low grade MALT lymphoma and high grade gDLBCL was hybridized to Agilent miRNA microarrays representing 795 human mature miRNAs. Unsu...
ORGANISM(S): Homo sapiens 
2010-10-02 | E-GEOD-24485 | biostudies-arrayexpress
TranscriptomicsThe minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus.
Objectives The antistaphylococcal pyrrolobenzodiazepine dimer ELB-21 forms multiple adducts with duplex DNA through covalent interactions with appropriately spaced guanine residues; it is now known to form interstrand and intrastrand adducts with oligonucleotide sequences of variable length. We dete...
ORGANISM(S): Staphylococcus aureus 
2011-04-15 | E-BUGS-115 | biostudies-arrayexpress
TranscriptomicsInfluence of Gross Ovarian Stage on Transcript Profiles in Fathead Minnow (Pimephales promelas) Ovary Tissue
Interpretation of toxicogenomic experiments conducted with ovary tissue from asynchronous-spawning small fish species are complicated by background variation in the relative abundance and proportion of follicles at different stages within the ovary tissue sample. This study employed both real-time ...
ORGANISM(S): Pimephales promelas 
2010-04-30 | E-GEOD-18254 | biostudies-arrayexpress
UnknownIntra-colony venom diversity contributes to maintaining eusociality in a cooperatively breeding ant.
Not available
S-EPMC9827630 | biostudies-literature
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