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TranscriptomicsGlobal profiling of gene expression in A signal mutants of Myxococcus xanthus
In response to starvation Myxococcus xanthus initiates a developmental program that culminates in the formation of fruiting bodies inside which the rod-shaped cells differentiate to spores. Fruiting body formation depends on intercellular communication and two intercellular signals are known, the A-...
ORGANISM(S): Myxococcus xanthus 
2012-05-17 | E-GEOD-18029 | biostudies-arrayexpress
TranscriptomicsPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60693 | biostudies-arrayexpress
UnknownDifferential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.
Not available
S-EPMC6328449 | biostudies-literature
TranscriptomicsChemical allergen-induced perturbations of the mouse lymph node DNA methylome
Epigenetic regulation of gene expression plays a pivotal role in the orchestration of immune responses and may determine the vigor, quality, or longevity of such responses. Chemical allergens can be divided into two categories: skin sensitizing chemicals associated with allergic contact dermatitis, ...
ORGANISM(S): Mus musculus 
2014-02-07 | E-GEOD-54768 | biostudies-arrayexpress
TranscriptomicsDynamic changes in liver 5-hydroxymethylcytosine profiles upon non-genotoxic carcinogen exposure [Replicated control vs. pb treated study]
Dynamic changes in the mouse liver DNA methylome associated with short (1 day) and prolonged (7, 28 and 91 days) exposure to the rodent liver non-genotoxic carcinogen (NGC), phenobarbital (PB). Full expression dataset (all time points: 1, 7, 28, 91 days) Replicated control vs. pb treated study
ORGANISM(S): Mus musculus 
2013-03-25 | E-GEOD-45465 | biostudies-arrayexpress
TranscriptomicsPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice [Expression array].
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest st...
ORGANISM(S): Mus musculus 
2011-12-14 | E-GEOD-34423 | biostudies-arrayexpress
TranscriptomicsPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice.
This SuperSeries is composed of the following subset Series: GSE34423: Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice [Expression array]. GSE34462: Phenobarbital mediates an epigenetic switch at the constituti...
ORGANISM(S): Mus musculus 
2011-12-16 | E-GEOD-34463 | biostudies-arrayexpress
TranscriptomicsPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice [MeDIP array].
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest st...
ORGANISM(S): Mus musculus 
2011-12-16 | E-GEOD-34462 | biostudies-arrayexpress
TranscriptomicsPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors (mRNA)
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcino- genesis. Here, we have used a humanized CAR/PXR mo...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60684 | biostudies-arrayexpress
TranscriptomicsPhenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors (miRNA)
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcino- genesis. Here, we have used a humanized CAR/PXR mo...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60688 | biostudies-arrayexpress
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