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ProteomicsSECRETORY PROTEOMIC RESPONSES OF ENDOMETRIAL EPITHELIAL CELLS TO TROPHOBLAST DERIVED EXTRACELLULAR VESICLES
Synchronized cross talk between embryo and endometrium during pre-implantation period is critical for establishment of pregnancy. Extracellular vesicels(EVs) of both embryo and endometrial origin are known to be integral in regulating embryo maternal communication during this time. However, exact mo...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040311 | Pride
Embryo Extracellular vesicles Lc-ms Endometrium Epithelial cells Trophoblast cells Secretome Proteomics 
ProteomicsDo extracellular vesicles have specific target cells? Extracellular Vesicle mediated embryo maternal communication
Extracellular vesicles (EVs) have emerged as key messengers in intercellular communications. However, the precise mechanisms of how recipient cells read EV messages are not clear. In this study, we investigated the roles of EV protein cargo, EV parent cell type, and recipient cell type in EV functio...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050024 | Pride
Jar cell line Extracellular vesicles Embryo implantation Hek 293 cell line 
ProteomicsEffect of 2D and 3D cell culture system on trophoblast extracellular vesicles physio-chemical characteristics and potency
In this project, trophoblast cell analogue human chorionic carcinoma cell line was cultivated in both conventional monolayer culture (2D) and as spheroids in suspension cultures (3D) and how the cell growth environment affects the physical and biochemical properties of EVs produced by them was studi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-08 | PXD048789 | Pride
Trophoblast cells Extracellular vesicles Embryo implantation 2d culture 3d culture 
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