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GenomicsEndogenous DAF-16 genome-wide recruitment under low Insulin signaling condition in Caenorhabditis elegans
In order to understand the complexity of gene regulation downstream of IIS, we used anti-DAF-16 antibody, we report the first genome-wide ChIP-sequencing study of endogenous DAF-16 recruitment in daf-2(e1370). We also report the average bin-wise normalized read count of ZFP-1 and DAF-16 on DAF-16 s...
ORGANISM(S): Caenorhabditis elegans 
2016-03-01 | E-GEOD-63865 | biostudies-arrayexpress
TranscriptomicsEndogenous DAF-16 genome-wide recruitment under low Insulin signalling condition in Caenorhabditis elegans
In order to understand the complexity of gene regulation downstream of IIS, we did RNA-seq in mixed culture in wild-type, daf-2(e1370), daf-16(mgDf50);daf-2(e1370) and daf-2(e1370);daf-12(m20 and correlated it with ChIP-seq data RNA-seq profile of different mutants in mix stage
ORGANISM(S): Caenorhabditis elegans 
2016-03-01 | E-GEOD-67975 | biostudies-arrayexpress
TranscriptomicsWhole genome microRNA expression profiling of long-lived daf-2(e1370) mutant in C. elegans at young adult stage
In order to get an insight into the complex interplay of miRNAs in insulin signaling, we profiled the small RNA polulation of daf-2(e1370) worms at young adult stage by Next Generation sequencing. We performed Next Generation sequencing to compare miRNA profiles of wild-type and long-lived daf-2(e13...
ORGANISM(S): Caenorhabditis elegans 
2014-11-27 | E-GEOD-61112 | biostudies-arrayexpress
TranscriptomicsWhole genome microRNA expression profiling during C. elegans dietary restriction
In order to get an insight into the complex interplay of miRNAs in dietary restriction, we profiled the small RNA polulation of wild-type and eat-2(ad1116) worms on Day 1 and Day 8 of adulthood by Next Generation sequencing. We compared the normalized expression of wild-type vs eat-2(ad1116) on eit...
ORGANISM(S): Caenorhabditis elegans 
2014-11-27 | E-GEOD-60155 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Caenorhabditis elegans at Late L4 stage of WT, daf-2(e1370), daf-16(mgDf50);daf-2(e1370) on control RNAi and cdk-12 RNAi
To check cdk-12 and DAF-16 dependent gene expression change in different genetic backgrounds. We have collected the synchronized late L4 worms and isolated the total RNA and did the mRNA sequencing.
ORGANISM(S): Caenorhabditis elegans 
2023-08-25 | E-MTAB-11189 | biostudies-arrayexpress
UnknownDifferential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity.
Alternative splicing (AS) coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here we show that, during dietary restriction (DR), AS is enhanced in Caenorhabditis elegans and mice. A splicing mediator hrpu-1 regulates a significant part of t...
S-EPMC5563511 | biostudies-literature
MetabolomicsMethionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met-C gen...

2025-07-05 | MTBLS12457 | MetaboLights
UnknownMethionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling.
The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met-C genes ...
S-EPMC12130505 | biostudies-literature
UnknownDietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis.
Unfolded protein response (UPR) of the endoplasmic reticulum (UPRER) helps maintain proteostasis in the cell. The ability to mount an effective UPRER to external stress (iUPRER) decreases with age and is linked to the pathophysiology of multiple age-related disorders...
S-EPMC6717303 | biostudies-literature
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