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TranscriptomicsDNA damage-induced HSPC failure depends on ROS accumulation downstream of IFN-1 signaling and Bid mobilization
Targeted mouse mutants with inactivated Mixed-Lineage-Leukemia-5 (Mll5, MGI:1924825) alleles exhibit numerical, cell cycle and functional abnormalities in their hematopoietic stem and progenitor cell (HSPC) compartments, including hyper-proliferation of otherwise quiescent hematopoietic stem cells, ...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-85076 | biostudies-arrayexpress
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
UnknownThe Trichoderma harzianum demon: complex speciation history resulting in coexistence of hypothetical biological species, recent agamospecies and numerous relict lineages.
Not available
S-EPMC2858147 | biostudies-literature
UnknownMiracle Fruit, a Potential Taste-modifier to Improve Food Preferences: A Review.
Not available
S-EPMC11489218 | biostudies-literature
UnknownAged murine hematopoietic stem cells drive aging-associated immune remodeling.
Not available
S-EPMC6137572 | biostudies-literature
UnknownShank3 related muscular hypotonia is accompanied by increased intracellular calcium concentrations and ion channel dysregulation in striated muscle tissue.
Not available
S-EPMC10511643 | biostudies-literature
UnknownRBPJ Deficiency Sensitizes Pancreatic Acinar Cells to KRAS-Mediated Pancreatic Intraepithelial Neoplasia Initiation.
Not available
S-EPMC10520364 | biostudies-literature
UnknownCD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants.
Not available
S-EPMC10228399 | biostudies-literature
UnknownIFN-γ treatment protocol for MHC-Ilo/PD-L1+ pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential.
Not available
S-EPMC7462314 | biostudies-literature
UnknownSingle-cell profiling of GP2-enriched pancreatic progenitors to simultaneously create acinar, ductal, and endocrine organoids.
Not available
S-EPMC10091881 | biostudies-literature
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