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TranscriptomicsRNA-seq data of acute leukemias of ambiguous lineage (ALAL)
We generated RNA-seq data of 30 cases of acute leukemia of ambiguous lineage (ALAL), including both bilineal and biphenotypic patients, in order to develop methods to improve the diagnosis of this disease. First, we used an in-house pipeline to comprehensively detect genetic lesions in RNA-sequencin...
ORGANISM(S): Homo sapiens 
2025-05-16 | E-MTAB-15145 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling (RNA-seq) of human acute leukemias and healthy donors
Total RNA-seq of blasts derived 100 adult T-ALL cases, 211 AML cases and 13 mixed myeloid/lymphoid leukemias with CpG Island Methylator Phenotype (CIMP). In addition, CD34+ HSPCs derived from 9 healthy donors are used as a control. Due to patient confidentiality considerations, the raw data files fo...
ORGANISM(S): Homo sapiens 
2023-08-31 | E-MTAB-13121 | biostudies-arrayexpress
GenomicsCTCF ChIP-seq of human acute leukemias
CTCF ChIP-seq of 39 primary samples derived from human acute leukemias, namely AML, T-ALL and mixed myeloid/lymphoid leukemias with CpG Island Methylator Phenotype (CIMP). Due to patient confidentiality considerations, the raw data files for this dataset have been deposited to the EGA controlled-acc...
ORGANISM(S): Homo sapiens 
2023-08-31 | E-MTAB-13117 | biostudies-arrayexpress
GenomicsH3K27ac ChIP-seq of human acute leukemias and healthy donors
H3K27ac ChIP-seq of 79 primary samples derived from human acute leukemias, namely AML, T-ALL and mixed myeloid/lymphoid leukemias with CpG Island Methylator Phenotype (CIMP). In addition, 4 samples derived from CD34+ cord blood cells of healthy donors were included. Due to patient confidentiality co...
ORGANISM(S): Homo sapiens 
2023-08-31 | E-MTAB-13119 | biostudies-arrayexpress
TranscriptomicsDNA methylation (MCIP-seq) of human acute leukemias and healthy donors
To measure methylation, we employed Methyl-CpG-immunoprecipitation (MCIP) a technique which relies on a fusion protein consisting of the methyl-binding domain (MBD) of MBD2 and the Fc portion of IgG1 to detect methylated regions, exploiting the natural preference of MBD for 5-methylcytosine (5-mC). ...
ORGANISM(S): Homo sapiens 
2023-08-31 | E-MTAB-13120 | biostudies-arrayexpress
GenomicsTF ChIP-seq of human acute leukemias
CEBPA/PU.1/TCF7 ChIP-seq of 6 primary samples derived from human acute leukemias, namely AML, T-ALL and mixed myeloid/lymphoid leukemias with CpG Island Methylator Phenotype (CIMP). Low-coverage whole genome sequencing (ChIP input) of the same samples is also included as a control to be used in peak...
ORGANISM(S): Homo sapiens 
2024-05-27 | E-MTAB-14060 | biostudies-arrayexpress
TranscriptomicsHi-C of human acute leukemias and healthy donors
Hi-C of 17 primary samples obtained from human acute leukemias, namely AML, T-ALL and mixed myeloid/lymphoid leukemias with CpG Island Methylator Phenotype (CIMP). As healthy controls, Hi-C of CD34+ HSPCs from 3 healthy donors were used. Due to patient confidentiality considerations, the raw data fi...
ORGANISM(S): Homo sapiens 
2023-08-31 | E-MTAB-13122 | biostudies-arrayexpress
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