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Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
TranscriptomicsRearrangement of CRLF2 in B-progenitor and Down syndrome associated acute lymphoblastic leukemia
Chromosomal aneuploidy and translocations are hallmarks of acute lymphoblastic leukemia (ALL), but many patients lack a recurring chromosomal alteration. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that results in the ex...
ORGANISM(S): Homo sapiens 
2009-10-18 | E-GEOD-16724 | biostudies-arrayexpress
TranscriptomicsEfficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations s...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-68391 | biostudies-arrayexpress
TranscriptomicsIntegrated Genetic and Epigenetic Analysis of Childhood ALL Reveals a Synergistic Role for Structural and Epigenetic Lesions In Determining Disease Phenotype
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-44862 | biostudies-arrayexpress
ProteomicsZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia
ZNF384-rearranged fusion oncoproteins (FO) define a subset of lineage ambiguous leukemias, but the mechanistic role of ZNF384 FO in leukemogenesis and lineage ambiguity is poorly understood. Here, using viral expression in mouse and human hematopoietic stem and progenitor cells (HSPCs) and a Ep300-Z...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD028481 | Pride
Znf384 Stem cell Leukemia Fusion oncoprotein Lineage ambiguous Mixed phenotype 
UnknownHigh Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
Not available
S-EPMC5455698 | biostudies-literature
UnknownDasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622.
Not available
S-EPMC6067800 | biostudies-literature
TranscriptomicsDefective K-Ras Oncoproteins Initiate Cancer In Vivo and Evolve to Overcome Impaired Effector Binding
The oncogenic proteins expressed in human cancer cells are exceedingly difficult targets for drug discovery due to intrinsic properties of the Ras GTPase switch. As a result, recent efforts have largely focused on inhibiting Ras-regulated kinase effector cascades, particularly the Raf/MEK/ERK and PI...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-28687 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse B cell progenitors
Gene expression profiling was performed of Pax5 wild type bone marrow subsets from common lymphoid progenitors through to Hardy stage F cells. These cells were obtained by flow sorting of bone marrow. Gene expression profiling was performed on 41 samples of RNA extracted from flow sorted B cell prec...
ORGANISM(S): Mus musculus 
2013-01-14 | E-GEOD-38463 | biostudies-arrayexpress
UnknownTP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.
Not available
S-EPMC5815403 | biostudies-literature
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