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GenomicsEpigenetic regulation of FLT3 by ZNF384-fusion protein
Epigenetic regulation of FLT3 by ZNF384-fusion protein
PRJNA812608 | ENA
ProteomicsZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia
ZNF384-rearranged fusion oncoproteins (FO) define a subset of lineage ambiguous leukemias, but the mechanistic role of ZNF384 FO in leukemogenesis and lineage ambiguity is poorly understood. Here, using viral expression in mouse and human hematopoietic stem and progenitor cells (HSPCs) and a Ep300-Z...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD028481 | Pride
Znf384 Stem cell Leukemia Fusion oncoprotein Lineage ambiguous Mixed phenotype 
ProteomicsZinc finger protein ZNF384 is an adaptor of KU to DNA during classical non-homologous end-joining
DNA double-strand breaks (DSBs) are among the most deleterious types of DNA damages as they can lead to mutations and chromosomal rearrangements, which underlie cancer development and progression. Non-homologous end-joining (NHEJ) is the dominant pathway for the repair of DSBs in human cells, which ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD020417 | Pride
Non homologous end joining  double strand break repair 
GenomicsZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia [HiChIP]
ZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia [HiChIP]
PRJNA752217 | ENA
GenomicsEpigenetic regulation of FLT3 by ZNF384-fusion protein
Profiling global gene expression in large ALL cohorts, we identified unique over-expression of FLT3 in ZNF384-rearranged ALL, consistently across cases harboring different fusion partners with ZNF384. Mechanistically, we discovered an intergenic enhancer element at the FLT3 locus that is exclusively...
ORGANISM(S): Homo sapiens 
2022-08-11 | GSE197890 | GEO
UnknownZNF384-ZEB1 feedback loop regulates breast cancer metastasis.
Not available
S-EPMC9469556 | biostudies-literature
GenomicsRNA-sequencing to investigate transcriptional changes caused by ZNF384 fusion proteins in murine pre-B cells
RNA-sequencing to investigate transcriptional changes caused by ZNF384 fusion proteins in murine pre-B cells
PRJNA448177 | ENA
GenomicsZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia [ChIP-seq]
ZNF384 fusion oncoproteins drive lineage aberrancy in acute leukemia [ChIP-seq]
PRJNA752731 | ENA
UnknownA novel class of ZNF384 aberrations in acute leukemia.
Not available
S-EPMC8579251 | biostudies-literature
UnknownZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.
Not available
S-EPMC9414741 | biostudies-literature
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