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TranscriptomicsTranscription profiling of human cord blood cells transduced with Leukemia fusion-gene
MLL-AF9 expression in normal human umbilical cord blood CD34+ cells leads to long-term proliferation of a myeloid progenitor cell with leukemogenic potential. Expression of a Core Binding Factor leukemia fusion (AML1-ETO or CBFbeta-SMMHC) in human CD34+ cells results in self-renewal of primitive pro...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7011 | biostudies-arrayexpress
TranscriptomicsRunx1/Cbfb deficiency effect on MLL-AF9 cells
To identify the target genes of Runx1/Cbfb in MLL fusion leukemia, we performed microarray analysis using control and Runx1/Cbfb-deleted MLL-AF9 cells. c-Kit(+) bone marrow cells derived from Runx1/Cbfb double floxed mice were transduced with MLL-AF9 and CreERT2 (coexpressing Puromycin). After seve...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-47350 | biostudies-arrayexpress
UnknownTargeting IRAK1 as a therapeutic approach for myelodysplastic syndrome.
Not available
S-EPMC3711103 | biostudies-literature
TranscriptomicsRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia
Epigenetic pathways regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. While chromatin alterations are...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-29799 | biostudies-arrayexpress
UnknownDialysis Facility Profit Status and Early Steps in Kidney Transplantation in the Southeastern United States.
Not available
S-EPMC8216615 | biostudies-literature
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