Multi-kinase inhibitor

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Transcriptomics (1162)
Unknown (943)
Genomics (172)
Proteomics (88)
Metabolomics (11)
Clinical (10)
Other (5)
Models (3)

Organisms

Mus musculus (488)
Homo sapiens (326)
Rattus norvegicus (143)
Sus scrofa (33)
Danio rerio (32)
Drosophila melanogaster (18)
Arabidopsis thaliana (14)
Caenorhabditis elegans (13)
Gallus gallus (13)
Bos taurus (11)
Ovis aries (9)
Daphnia magna (8)
Xenopus laevis (8)
Saccharomyces cerevisiae (8)
Macaca mulatta (7)
Macaca fascicularis (6)
Oikopleura dioica (3)
Streptococcus pneumoniae (3)
Salmo salar (3)
Oryctolagus cuniculus (3)
Vibrio cholerae (3)
Aplysia californica (2)
Prochlorococcus marinus subsp. pastoris str. CCMP1986 (2)
Pimephales promelas (2)
Papio anubis (2)
Ciona intestinalis (2)
Papio hamadryas (2)
Equus caballus (2)
Schistosoma mansoni (2)
Rattus rattus (2)

Organisms

Homo sapiens (62)
Mus musculus (18)
Rattus norvegicus (3)
Homo (1)
Canis lupus familiaris (1)
Mus musculus musculus (1)
Danio rerio (1)

Repository

biostudies-arrayexpress (1150)
ENA (106)
geo (75)
pride (63)
EGA (11)
MetaboLights (11)
jPOST (9)
iProX (8)
MassIVE (8)
BioModels (2)
GPMDB (2)
Cell Collective (1)
EVA (1)
LINCS (1)

Tissue

Cell culture (14)
Lung (8)
Brain (6)
Permanent cell line cell (4)
Epithelial cell (3)
Skin (3)
T cell (3)
Type II pneumocyte (3)
Colonic mucosa (2)
Liver (2)
Stromal cell of bone marrow (2)
B cell (1)
Bile duct (1)
Blood (1)
Cell suspension culture (1)
Cerebral cortex neuron (1)
Early embryonic cell (1)
Heart (1)
Hippocampal pyramidal neuron (1)
Keratinocyte (1)
Monocyte (1)
Neuron (1)
Ovarian surface epithelial cell (1)
Peripheral blood mononuclear cell (1)
Plant cell (1)
Primary cell (1)
Pyramidal neuron (1)
Stem cell (1)
Whole body (1)

Disease

Normal (10)
Alzheimer's disease (4)
Pancreatic ductal adenocarcinoma (2)
Retinoblastoma (1)
Lung Cancer (1)
Perineural invasion (1)
T. circumcincta infection (1)
Not applicable (1)
Ischaemia reperfusion injury (1)
Pneumococcal meningitis (1)
Imatinib-resistant CML cell line subclone (1)
Infected (1)
Liposarcoma (1)
Oligodendroglioma (1)
Mesothelioma (1)
Dukes D primary colon cancer (1)
Colon cancer metastasis (1)
Fibrosis (1)
Infected (1)
Rheumatoid arthritis (1)
None- acute control (1)
Non-infected (1)
IBDV infected (1)
Benign adenoma (1)
None- Acute Control (1)
Acute promyelocytic leukemia (1)
Glioblastoma (1)
Prostate cancer (1)
Prostate carcinoma (1)
Adenocarcinoma (1)

Technology Type

Mass Spectrometry (63)
Shotgun proteomics (31)
Affinity purification coupled with mass spectrometry proteomics (18)
Bottom-up proteomics (13)
Mass spectrometry (7)
Top-down proteomics (5)
Mass spectrometry assay (4)
Gel-based experiment (3)
Data-dependent acquisition (2)
Data-independent acquisition (2)
Infinium_OmniExpress-24v1.0 (1)
Fluorescence imaging (1)
Fluorescence intensity (1)
Immunopeptidomics (1)

Instrument Platform

Illumina NovaSeq 6000 (23)
Illumina HiSeq 2500 (20)
Illumina HiSeq 4000 (19)
NextSeq 500 (14)
Illumina HiSeq 2000 (10)
Axon GenePix 4000B scanning hardware (6)
Illumina MiSeq (5)
Illumina HiSeq 3000 (5)
Genepix (4)
GenePix Professional 4200A [Axon Instruments] (3)
ScanArray Express HT [PerkinElmer] (3)
Scanning hardware (3)
Agilent High resolution C scanner (2)
GenePix 4000A [Axon Instruments] (2)
BAS-5000 [FUJIFILM] (2)
Illumina Genome Analyzer IIx (2)
G2565BA DNA microarray scanner [Agilent] (2)
Illumina HiSeq 1500 (2)
NanoString nCounter (1)
IEO HPC (1)
Sequel II (1)
GeneChip Scanner 2500 (1)
Affymetrix Fluidics Station FS450; Affymetrix GeneChip Scanner 3000 7G (1)
Affymetrix Mouse Gene 1.0 ST (1)
Agilent C scanner (1)
Beckman Coulter MoFlo XDP (1)
High resolution C. scanner (1)
SureScan Dx (1)
Becton Dickinson INFLUX (1)
Agilent G2565BA scanner (1)

Publication Date

2010 (146)
2015 (124)
2014 (124)
2013 (119)
2012 (113)
2011 (83)
2008 (83)
2016 (66)
2007 (55)
2009 (53)
2005 (43)
2022 (41)
2025 (37)
2024 (36)
2021 (36)
2023 (35)
2026 (29)
2018 (27)
2020 (21)
2006 (19)
2019 (16)
2017 (15)
2004 (5)
2003 (2)

CHEBI ID

CHEBI:60050 (1)
CHEBI:1156 (1)
CHEBI:133617 (1)
CHEBI:30660 (1)
CHEBI:15366 (1)
CHEBI:28832 (1)
CHEBI:34498 (1)
CHEBI:18258 (1)
CHEBI:17566 (1)
CHEBI:23965 (1)
CHEBI:16135 (1)
CHEBI:30776 (1)
CHEBI:30768 (1)
CHEBI:18211 (1)
CHEBI:28484 (1)
CHEBI:30772 (1)
CHEBI:17295 (1)
CHEBI:16828 (1)
CHEBI:35697 (1)
CHEBI:16946 (1)
CHEBI:18089 (1)
CHEBI:17418 (1)
CHEBI:17992 (1)
CHEBI:17189 (1)
CHEBI:30746 (1)
CHEBI:17533 (1)

Metabolite Name

N-Acetyl-L-alanine (6)
N-Acetylhistamine (5)
Agmatine (5)
N6-methyladenosine (5)
L-Homoserine (5)
Phosphoenolpyruvate (5)
Xanthosine (5)
N4-Acetylcytidine (5)
Thymine (5)
Sarcosine (5)
5'-Deoxyadenosine (5)
Guanosine (5)
Inosine (5)
Benzoic acid (5)
N-Acetyl-L-phenylalanine (5)
Uridine (5)
Riboflavin (5)
Serotonin (5)
Ectoine (5)
Purine (5)
Creatine (5)
Adenosine (5)
Hippuric acid (5)
Choline (5)
Phenylalanylisoleucine (4)
Alpha-Muricholic acid (4)
2-Naphthalenesulfonic acid (4)
Butyric acid (4)
N,N-Dimethylaniline (4)
3, 5-Tetradecadiencarnitine (4)

First Public Date

2026 (24)
2025 (20)
2024 (16)
2023 (10)
2014 (8)
2021 (6)
2022 (5)
2017 (4)
2020 (3)
2019 (3)
2018 (3)
2015 (2)
2016 (1)
2013 (1)

Modelling Approach

Ordinary differential equation model (1)

Study status

Completed (4)
Not provided (3)
No longer available (1)
Active, not recruiting (1)
Recruiting (1)

Lab affiliation

Drug Discovery Moffitt Cancer Center Tampa, FL, USA (4)
Thoracic Oncology Molecular Medicine Program Moffitt Cancer Center Tampa, FL, USA (4)
BCMP, Harvard Medical School, Boston, USA Cancer Biology, Dana-Farber Cancer Institute, Boston, USA (2)
Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Canada (2)
Department of Pharmacology University of North Carolina - Chapel Hill Chapel Hill, NC 27599 (2)
Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361005, China (2)
Moffitt Cancer Center Tampa, FL (2)
Shenzhen People’s Hospital (2)
1Department of Neuroscience & Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA (1)
1Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA. Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA (1)
COld Spring Harbor Laboratory (1)
Chair of Proteomics and Bioanalytics Technical University of Munich Partner Site of the German Cancer Consortium (1)
Chair of Proteomics and Bioanalytics Technische Universitaet Muenchen Partner Site of the German Cancer Consortium Emil Erlenmeyer Forum 5 85354 Freising Germany (1)
Chair, Quantitative Proteomics Director, Proteome Center Tuebingen Interfaculty Institute for Cell Biology University of Tuebingen Auf der Morgenstelle 15 72076 Tuebingen Germany (1)
DZNE Munich Neuroproteomics Feodor-Lynen-Str. 17 81377 Munich Germany (1)
Department Cell Biology of the Skin, Cologne Excellence Cluster for Stress Responses in Ageing-associated diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne 50931, Germany (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 Arkansas Children's Research Institute, Little Rock, AR (1)
Department of Biochemistry, Western University (1)
Department of Biomedical Sciences, Jepps lab, University of Copenhagen, Denmark (1)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (1)
Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA. Systems Biology Institute, Yale University, New Haven, CT 06516, USA (1)
Department of Integration of Chinese and Western Medicine, Peking University Cancer Hospital and Institute (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic (1)
Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany (1)
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, 844102, Bihar, India (1)
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy (1)
Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience,School of Medicine, Xiamen University, Xiangan South Road, Xiamen, Fujian, 361102 P. R. China (1)
Head of Drug Discovery and Evaluation Center for Research of Pathogenicity and Virulence of Parasites Charles University in Prague, BIOCEV Průmyslová 595 252 50 Vestec Czech Republic (1)
Head of Drug Discovery and Evaluation Center for Research of Pathogenicity and Virulence of Parasites Charles University in Prague, BIOCEV Průmyslová 595 252 50 Vestec Czech Republic (1)

Keyword

Regorafenib (3)
HERCEPTIN*EV 1FL 150MG (1)
TYVERB*70CPR RIV 250MG (1)
Multi-Kinase Inhibitor (1)
Multi-kinase inhibitor (1)
Microsatellite stability (1)
Lapatinib (1)
JS001 (1)
Liver Cancer (1)
Kidney Cancer (1)
Targeted therapy (1)
Ado-Trastuzumab Emtansine (1)
Maytansine (1)
Folic Acid (1)
FOLFOX (1)
Liver metastases (1)
FOLFIRI (1)
Esomeprazole (1)
Trastuzumab (1)
Pertuzumab (1)
Leucovorin (1)
Levoleucovorin (1)
Oxaliplatin (1)

IsPrivate

False (2)

Study type

Transcription profiling by array (853)
RNA-seq of coding RNA (115)
ChIP-seq (33)
Unknown experiment type (19)
Methylation profiling by high throughput sequencing (14)
Comparative genomic hybridization by array (13)
RNA-seq of non coding RNA (12)
Other (11)
RNA-seq of coding RNA from single cells (11)
Animal - High-throughput sequencing (8)
ChIP-chip by array (7)
Animal - One-color microarray (6)
ChIP-chip by tiling array (6)
Transcription profiling by tiling array (5)
MicroRNA profiling by array (4)
Methylation profiling by array (4)
DNA-seq (3)
One-color microarray (2)
Cell line - High-throughput sequencing (2)
Single nucleus RNA sequencing (2)
Transcription profiling by SAGE (1)
Differential (1)
Human - High-throughput sequencing (1)
Cell line - One-color microarray (1)
High-throughput sequencing (1)
Human - One-color microarray (1)
CLIP-seq (1)
Transcription profiling by RT-PCR (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)

Release Date

2010 (156)
2014 (155)
2015 (149)
2022 (148)
2013 (138)
2021 (130)
2012 (127)
2023 (120)
2016 (119)
2011 (100)
2025 (96)
2024 (94)
2008 (86)
2020 (83)
2018 (82)
2009 (59)
2019 (55)
2007 (53)
2017 (52)
2005 (43)
2026 (20)
2006 (19)
2004 (5)
2003 (2)
2002 (1)

Location

Germany (3)
Italy (3)
United States (3)
Spain (2)
Belgium (2)
Canada (2)
Netherlands (2)
Australia (2)
United Kingdom (2)
Japan (2)
Finland (1)
Norway (1)
Ireland (1)
Denmark (1)
Portugal (1)
Mexico (1)
Greece (1)
Russia (1)
China (1)
Poland (1)
France (1)
Israel (1)
Czechia (1)
Hungary (1)
Austria (1)
Switzerland (1)
Sweden (1)

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AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity

Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...

ORGANISM(S): Homo sapiens

2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress

Genes regulated by PCK Inhibitors, enzastaurin and Go, in CAL-27 cells, a SCCHN cell line

Efficacy of the Multi-Kinase Inhibitor Enzastaurin is Dependent on Cellular Signaling Context Testing a panel of SCCHN cell lines revealed variable sensitivity to enzastaurin which correlated significantly with baseline cyclin D1 protein expression. Moreover, sensitivity and resistance could be reve...

ORGANISM(S): Homo sapiens

2010-07-12 | E-GEOD-22811 | biostudies-arrayexpress

Single cell RNA-seq of pancreatic mouse tumors upon treatment

KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted therapies, immune checkpoint blockade and engineered T cells. In this study, we performed a systematic high throughput combinatorial drug screen and identified a synergistic interaction between ...

ORGANISM(S): Mus musculus

2021-11-13 | E-MTAB-9954 | biostudies-arrayexpress

Integrative analysis of Multi-omics data of FGFR inhibitor

Dissection of the mechanism of action of FGFR inhibitor by multi-omic analysis

ORGANISM(S): Homo Sapiens

2025-02-05 | PXD060496 |

AUTOPHAGY INHIBITION IMPROVES SENSITIVITY TO THE MULTI-KINASE INHIBITOR REGORAFENIB IN PRECLINICAL MOUSE COLON TUMOROIDS

PRJNA1263506 | ENA

AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity

ORGANISM(S): Homo sapiens

2012-07-20 | GSE38008 | GEO

Transcription profiling of rat model of pumonary hypertension revals a multi- kinase inhibitor modulates pulmonary hypertension

Pulmonary hypertension (PH) and cancer pathophysiology share common signal transduction pathways leading to abnormal endothelial and smooth muscle cell interactions and angioproliferative vasculopathy. Sorafenib (Sor) a drug in clinical trials for cancer treatment, is an inhibitor of multiple kinase...

ORGANISM(S): Rattus norvegicus

2008-06-16 | E-GEOD-8134 | biostudies-arrayexpress

The discovery of aurora kinase inhibitor by multi-docking-based virtual screening.

Not available

S-EPMC4264174 | biostudies-literature

A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis therapy.

Not available

S-EPMC9386018 | biostudies-literature

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A.

Not available

S-EPMC7234811 | biostudies-literature