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MetabolomicsIntegrative multi-omics, HPLC fingerprinting and machine learning reveal distinct differences among three Dendrobium species from the Dabie Mountains
Dendrobium species are widely used in traditional Chinese medicine owing to their medicinal and nutritional value, yet the phytochemical diversity and molecular mechanisms underlying theirbioactivities remain poorly understood. To elucidate these traits, we performed an integrative multi-omics study...
2026-06-28 | MTBLS14876 | MetaboLights
MetabolomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Multi-omics analyses are increasingly employed in microbiome studies to obtain a holistic view of molecular changes occurring within microbial communities exposed to different conditions. However, it is not always clear to what extent each omics data type contributes to our understanding of the comm...
2022-12-08 | MTBLS3129 | MetaboLights
TranscriptomicsMulti-layer omics dataset for cross-species translational systems biology
Inferring in humans biological responses to external cues such as drugs, chemicals, viruses and hormones, is an essential question in biomedicine and cannot be easily studied in humans. Thus, biomedical research has continuously relied on animal models for studying the impact of these compounds and ...
ORGANISM(S): Rattus norvegicus 
2014-06-10 | E-MTAB-2091 | biostudies-arrayexpress
MetabolomicsMechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain a deeper mechanistic insight into the SSC biological activity and metabolization, a multi-omi...
2024-08-08 | MTBLS7424 | MetaboLights
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
MetabolomicsIntegrative Omics Analysis of Plant-Microbe Synergies in Petroleum Pollution Remediation

As the petrochemical industry continues to advance, the exacerbation of ecological imbalance and environmental degradation due to petroleum pollution is increasingly pronounced. The synergistic interaction between plants and microorganisms are pivotal in the degradation of petroleum hydrocarbons;...

2025-05-16 | MTBLS11700 | MetaboLights
MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined multi-system intera...

2025-12-16 | MTBLS13513 | MetaboLights
MetabolomicsMulti-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis

Hunner-type interstitial cystitis/bladder pain syndrome (HIC) is a complex and clinically challenging chronic disorder characterized by bladder-centered symptoms, including persistent pelvic pain and urinary urgency frequency, with elusive pathogenesis involving poorly defined mult...

2025-12-16 | MTBLS13512 | MetaboLights
MetabolomicsMulti-Omics Analysis Reveals Alcohol exposure affects Ferroptosis pathway in Brain

Alcohol-related brain damage (ARBD) constitutes a major global public health issue and is often comorbid with neuropsychiatric disorders such as Alzheimer's and Parkinson's diseases. Ferroptosis, a form of regulated cell death characterized by iron dependency and lipid peroxidation, has been impl...

2026-03-11 | MTBLS14025 | MetaboLights
MetabolomicsMulti-omics analysis revealed the aromatic compound metabolism in marine Roseobacter clade

Here, we selected Roseovarius nubinhibens as the model organism to comprehensively interrogate aromatic compound metabolism in marine Roseobacter clade. First, we preliminarily elucidated the three distinct mechanisms of aromatic compound transmembrane transport in R. nubinhibens. By integrating ...

2025-08-09 | MTBLS12306 | MetaboLights
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