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Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling
Pregnancy poses unique hemodynamic and metabolic demands on the heart. We postulated that the repetitive biological and hemodynamic impact of multiple pregnancies could cause persistent myocardial remodelling providing a substrate for subsequent HFpEF. Here we report that C57Bl/6J female mice at 24 ...
ORGANISM(S): Mus musculus 
2026-08-11 | GSE289403 | GEO
It is widely accepted that a woman’s lifetime risk of developing breast cancer at menopause is reduced by early full term pregnancy and multiparity. This phenomenon is associated with the development and differentiation of the breast, which ultimately imprints a specific genomic profile in the mam...
ORGANISM(S): Homo sapiens 
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