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ProteomicsiEvaluation of spin columns for human plasma depletion to facilitate MS-based proteomics analysis of SARS-cov-2 positive plasman columns for human plasma depletion to facilitate MS-based proteomics analysis of SARS-cov-2 positive plasma
the benefit on the number of identified proteins is well documented and the depletion step remains widely used in in-depth proteomics. Recently, single-use depletion spin columns have been developed (i.e High Select™ Top14 Abundant Protein Depletion Mini Spin Columns, Thermo) which greatly reduces ...
ORGANISM(S): Homo sapiens (Human) Macaca mulatta (Rhesus macaque) 
2021-07-30 | PXD023148 | Pride
Proteomics Mass spectrometry Plasma Depletion Sars-cov-2 Human Spin-column 
TranscriptomicsTranscription profiling of mouse multiple myeloma tumors and splenic B cells from transgenics overexpressing XBP-1s
Multiple myeloma (MM) evolves from highly prevalent premalignant condition termed Monoclonal Gammopathy of Undetermined Significance (MGUS). We report an MGUS-MM phenotype arising in transgenic mice with Emu-directed expression of the unfolded protein/ER stress response and plasma cell development ...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-6980 | biostudies-arrayexpress
TranscriptomicsExpression of MERTK based on Multiple Sclerosis (MS) risk haplotype
Whole transcriptome RNA-seq analysis to measure group-wise RNA expression level of the MERTK gene in 3 healthy controls (known to be homozygous non-risk haplotype at MERTK gene locus) and to compare this to the group-wise RNA expression level of the MERTK gene in 5 Multiple Sclerosis-affected (MS-af...
ORGANISM(S): Homo sapiens 
2016-02-06 | E-GEOD-77598 | biostudies-arrayexpress
TranscriptomicsIdentification of MicroRNA Expression Patterns and a MicroRNAs/mRNA Regulatory Network in Multiple Myeloma
To date, little evidence of miRNA expression/deregulation in multiple myeloma (MM) has been reported. To characterize miRNA expression profiling of MM plasma cells (PCs) and integrate miRNA expression data with other molecular features of MM patients, global miRNA expression profiles were generated ...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-17498 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies
Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerï¾’s disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothac...
ORGANISM(S): Mus musculus 
2008-07-12 | E-MTAB-1 | biostudies-arrayexpress
Transcriptomicslongitudinal expression profiling in whole blood of multiple sclerosis patients and controls [IFN_replication dataset]
Multiple sclerosis is the most common autoimmune disease of the central nervous system. Studying whole blood RNA from a cohort of 195 MS patients and 66 healthy controls, we identified gene expression signatures for interferon treatment and disease status by microarray analysis. Blood was collected ...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-41847 | biostudies-arrayexpress
Transcriptomicslongitudinal expression profiling in whole blood of multiple sclerosis patients and controls [IFN_discovery dataset]
Multiple sclerosis is the most common autoimmune disease of the central nervous system. Studying whole blood RNA from a cohort of 195 MS patients and 66 healthy controls, we identified gene expression signatures for interferon treatment and disease status by microarray analysis. Blood was collected ...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-41846 | biostudies-arrayexpress
Transcriptomicslongitudinal expression profiling in whole blood of multiple sclerosis patients and controls [MS vs Ctrl Discovery dataset]
Multiple sclerosis is the most common autoimmune disease of the central nervous system. Studying whole blood RNA from a cohort of 195 MS patients and 66 healthy controls, we identified gene expression signatures for interferon treatment and disease status by microarray analysis. Blood was collected ...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-41848 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of multiple myeloma bone marrow
Bone marrow microenvironment in MM contains a unique miR signature, which is partially present and detectable in the peripheral blood. A subset of miRs (let-7i, miR-106b, miR-15a, and miR16) shows aberrant expression in the precursor lesion of MGUS, while aberrant expression of other miRs (let-7a, m...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-49261 | biostudies-arrayexpress
TranscriptomicsGene expression profile of myeloma cells treated with IGF-1
Objective of this study was to find changes in gene expression of mouse multiple myeloma cells upon treatment with IGF-1 Murine multiple myeloma cells were incubated in serum free medium for 12 hours in the absence (3 replicates) or presence (3 replicates) of 100 ng/ml IGF-1
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-17140 | biostudies-arrayexpress
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