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TranscriptomicsCentrosome associated genes pattern for risk sub-stratification in multiple myeloma
This experiment follows, extends and validates our previous findings published in Leukemia & Lymphoma as original article entitled \Molecular heterogeneity and centrosome-associated genes in multiple myeloma\. [Kryukov F, Nemec P, et al, Leuk Lymphoma. 2013 Sep;54(9):1982-8. Doi: 10.3109/10428194.2...
ORGANISM(S): Homo sapiens 
2016-05-01 | E-MTAB-4032 | biostudies-arrayexpress
TranscriptomicsSystematically characterizing dysfunctional long intergenic non-coding RNAs in multiple brain regions of major psychosis
Schizophrenia (SZ) and bipolar disorder (BD) are severe neuropsychiatric disorders with serious impact on patients, together termed major psychosis. Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important roles in mental diseases. However, little was known about their mo...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78936 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of multiple brain regions in Parkinson's disease
Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the following subset Series: GSE20168: Transcriptional...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-20295 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human newly diagnised multiple myeloma patients prior to treatment
Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients Experiment Overall Design: Samples in this series are: CD-138-selected plasma cells from bone marrow of newly diagnosed multiple myeloma patients susequently treated with Total Therapy
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4452 | biostudies-arrayexpress
TranscriptomicsIn Vivo Mapping of Arabidopsis Scaffold/Matrix Attachment Regions Reveals Link to Nucleosome-Disfavoring Poly(dA:dT) Tracts
Scaffold or matrix attachment regions (S/MARs) are found in all eukaryotes. The pattern of distribution and genomic context of S/MARs is thought to be important for processes such as chromatin organization and modulation of gene expression. Despite the importance of such processes, much is unknown a...
ORGANISM(S): Arabidopsis thaliana 
2014-02-03 | E-GEOD-45549 | biostudies-arrayexpress
GenomicsTargeted resequencing of ribosomal proteins in multiple myeloma patient samples.
We studied 38 multiple myeloma samples to discover mutations in ribosomal proteins. To this end, we ran a specifically designed targeted resequencing study to resequence the coding regions of all ribosomal proteins.
EGAS00001002405 | EGA
TranscriptomicsMultiple Sclerosis Blood Cell mRNA Transcriptome
We measured mRNA expression for all known genes in whole blood from 144 individuals, 99 with MS (43 PPMS, 36 RRMS and 20 SPMS). Analysis of gene expression and genotype in these individuals has indicated the dominant genetic association with T cell regulation is matched by the dominant pattern of dy...
ORGANISM(S): Homo sapiens 
2010-04-13 | E-GEOD-17048 | biostudies-arrayexpress
TranscriptomicsIdentification of MicroRNA Expression Patterns and a MicroRNAs/mRNA Regulatory Network in Multiple Myeloma
To date, little evidence of miRNA expression/deregulation in multiple myeloma (MM) has been reported. To characterize miRNA expression profiling of MM plasma cells (PCs) and integrate miRNA expression data with other molecular features of MM patients, global miRNA expression profiles were generated ...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-17498 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human purified plasma cells (PCs) obtained from 90 newly diagnosed multiple myeloma (MM) reveals a distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma
Background and objective: The chromosome 13 deletion (del(13)) represents one of the most frequent chromosomal alterations in multiple myeloma (MM). del(13) is associated with an unfavorable prognosis, although there is an increasing agreement that its prognostic relevance has to be related to the p...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6365 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in mouse brain regions after exposure to 1.9 GHz continuous-wave radiofrequency fields
This study assessed changes in gene expression in 7 mouse brain regions using Illumina Mouse WG-6 (v2) beadchips after exposure to 1.9 GHz continuous-wave radiofrequency field exposure for 4h/day for 5 days. High dose RF field exposure was whole body average SAR and brain average SAR were 1.36 W/kg ...
ORGANISM(S): Mus musculus 
2016-04-22 | E-MTAB-4675 | biostudies-arrayexpress
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