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MetabolomicsComprehensive High-Resolution Multiple-Reaction Monitoring Mass Spectrometry for Targeted Eicosanoid Assays
Eicosanoids comprise a class of bioactive lipids derived from a unique group of essential fatty acids that mediate a variety of important physiological functions. Owing to the structural diversity of these lipids, their analysis in biological samples is often a major challenge. Advancements in mass ...
2018-06-26 | MTBLS641 | MetaboLights
MetabolomicsLiquid Chromatography-Mass Spectrometry Quantification of Phytochemicals in Withania somnifera Using Data-Dependent Acquisition, Multiple-Reaction-Monitoring, and Parallel-Reaction-Monitoring with an Inclusion List

Characterization of botanical extracts by mass spectrometry-based metabolomics analysis helps in determining the phytochemical composition that underlies their bioactivity and potential health benefits, while also supporting reproducibility of effects in clinical trials. The quantification of sev...

2024-07-10 | MTBLS10418 | MetaboLights
MetabolomicsOn-line targeted metabolomics for real-time monitoring of relevant compounds in fermentation processes
Fermentation monitoring is a powerful tool for bioprocess development and optimisation. On-line metabolomics is a technology that is starting to gain attention as a bioprocess monitoring tool, allowing the direct measurement of many compounds in the fermentation broth at a very high time resolution....
2024-03-05 | MTBLS7889 | MetaboLights
ProteomicsMRM (Multiple Reaction Monitoring) quantitation of the blood plasma and serum samples from healthy donors
Using 30 synthetic bacterial peptides as external standards, we quantified the abundance of identified peptides in the serum and plasma by multiple reaction monitoring (MRM). Of these 30 peptides, 15 were quantified reliably.
ORGANISM(S): Homo sapiens (Human) 
2024-06-14 | PXD027793 | Pride
Peptidomics Multiple reaction monitoring Mass spectrometry Mrm Blood plasma and serum Healthy donors 
ProteomicsClinical Assay for the Early Detection of Colorectal Cancer Using Mass Spectrometric Wheat Germ Agglutinin Multiple Reaction Monitoring
Colorectal cancer (CRC) is currently the third leading cause of cancer related mortality in the world. U.S. Food and Drug Administration-approval circulating tumor markers, including carcinoembryonic antigen, carbohydrate antigen (CA) 19-9 and CA125, were used as prognostic biomarker of CRC that att...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD024997 | Pride
Colorectal cancer  multiple reaction monitoring  tandem mass spectrometer  wheat germ agglutinin  plasma 
ProteomicsMining Missing Membrane Proteins by High-pH Reverse Phase StageTip Fractionation and Validation by Multiple Reaction Monitoring Mass Spectrometry
Several significant efforts have been made in the past decade to map all human proteome. However, more than 3000 proteins are grouped as missing having no evidence of translation. Membrane protein annotation of the current missing proteins list showed 34%to be missing membrane proteins, which are ch...
ORGANISM(S): Homo sapiens (Human) 
2015-07-27 | PXD002224 | Pride
High-ph reverse phase Stagetip Missing proteins Lung cancer 
ProteomicsHST-MRM-MS: A Novel High-Sample-Throughput Multiple Reaction Monitoring Mass Spectrometric Method for Multiplex Absolute Quantitation of Hepatocellular Carcinoma Serum Biomarker
Absolute quantification of clinical biomarkers by mass spectrometry (MS) has been challenged due to low sample-throughput of current multiple reaction monitoring (MRM) methods. For this problem to be overcome, in this work, a novel high-sample-throughput multiple reaction monitoring mass spectrometr...
ORGANISM(S): Homo Sapiens 
2020-02-23 | PXD040708 |
ProteomicsMultiple reaction monitoring assay for differentiating gastric cancer from acid peptic diseases
Gastric cancers (GCs) are often diagnosed in advanced stages, owing to non-specific clinical symptoms at early stages that resemble Acid Peptic Diseases (APDs). Despite recent efforts, a simple, liquid biopsy-based, multi-protein panel pre-diagnostic assay that can differentiate GCs from APDs is lac...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD064371 | Pride
Laboratory developed test Multiple reaction monitoring Gastric cancer Qtrap 6500 
ProteomicsQuantification of cytokines secreted by primary human cells using MRM: evaluation of analytical parameters â?? shotgun secretome data of inflammatory stimulated HUVECs
The determination of secreted proteins may provide highly valuable information about cell functions. While the typical methods for the determination of biologically relevant but low-abundant molecular species still relies on the use of specific antibodies, mass spectrometry-based methods are now gai...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079982 | MassIVE
ProteomicsQuantification of cytokines secreted by primary human cells using MRM: evaluation of analytical parameters â?? shotgun secretome data of untreated HUVECs
The determination of secreted proteins may provide highly valuable information about cell functions. While the typical methods for the determination of biologically relevant but low-abundant molecular species still relies on the use of specific antibodies, mass spectrometry-based methods are now gai...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079983 | MassIVE
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