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Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
Multiplexed protein and drug imaging by super-resolution ion beam imaging
Precise immuno-fluorescence canceling enables highly multiplexed imaging [RNA-seq]
Precise immuno-fluorescence canceling enables highly multiplexed imaging [scRNA-seq]
Multiplexed imaging of nucleome architectures in single cells of mammalian tissue
Precise immuno-fluorescence canceling enables highly multiplexed imaging
Deciphering the intricate tumor-immune interactions within the microenvironment is crucial for advancing cancer immunotherapy. Here, we introduced mipDVP, an advanced approach integrating highly multiplexed imaging, single-cell laser microdissection, and sensitive mass spectrometry to spatially prof...
ORGANISM(S): Homo sapiens (Human) 
2024-12-19 | PXD057118 | Pride
Multichrome encoding-based multiplexed, spatially resolved imaging reveals single-cell RNA epigenetic modifications heterogeneity
Knowledge of the expression profile and spatial landscape of the transcriptome in individual cells is essential for understanding the rich repertoire of cellular behaviors. Here we report multiplexed error-robust fluorescence in situ hybridization (MERFISH), a single-molecule imaging approach that a...
ORGANISM(S): Homo sapiens 
multiplexed RNA imaging of human forebrain organoids from typical and autism subjects [MERFISH]
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