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TranscriptomicsMicroarray analysis of surgical liver biopsies from 13 obese (nine with type 2 diabetes) and five control subjects
Hepatic lipid accumulation is an important complication of obesity linked to risk for type 2 diabetes. To identify novel transcriptional changes in human liver which could contribute to hepatic lipid accumulation and associated insulin resistance and type 2 diabetes (DM2), we evaluated gene expressi...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-15653 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal muscle from diabetic or non-diabetic Mexican Americans with or without a family history of diabetes
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulati...
ORGANISM(S): Homo sapiens 
2007-06-28 | E-CBIL-28 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle - type 2 diabetes and family history positive individuals - Mexican American
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulati...
ORGANISM(S): Homo sapiens 
2010-04-27 | E-GEOD-21340 | biostudies-arrayexpress
UnknownMutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Not available
S-EPMC5819591 | biostudies-literature
TranscriptomicsIncreased SRF Transcriptional Activity is a Novel Signature of Insulin Resistance in Humans and Mice
Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) and is even present in offspring of diabetic parents. However, molecular mediators of insulin resistance remain unclear. We find that the top-ranking gene set in expression analysis of muscle from humans w...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-25462 | biostudies-arrayexpress
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