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ProteomicsLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, Carr SA, Ebert BL. Science 2014, 343, 301-305. doi:10.1126/science.1244851. Lenalidomide is a drug with clinical efficacy in multiple myeloma an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-26 | MSV000079017 | MassIVE
TranscriptomicsGene expression profile alone is inadequate in predicting complete response in multiple myeloma
We have analyzed gene expression microarray datasets from four different clinical trials to assess accuracy of gene expression based signature in predicting treatment complete response in patients with multiple myeloma. Two of four datasets were made available via The Intergroupe Francophone du Myél...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-55145 | biostudies-arrayexpress
TranscriptomicsGenetic adaptability of cancer cells under treatment selection pressure in multiple myeloma patients.
Purpose Despite advances and significant improvement in survival, multiple myeloma (MM) remains incurable and nearly all patients relapse after treatment. Previous studies have shown a complex spectrum of diverse genetic alterations in almost all patients, but evolution of genomic rearrangements th...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-25262 | biostudies-arrayexpress
TranscriptomicsMinor clone provides a reservoir for relapse in multiple myeloma
In this study we addressed subclonal evolutionary process after treatment and subsequent relapse in multiple myeloma (MM) in a cohort of 24 MM patients treated either with conventional chemotherapy or with the proteasome inhibitor, bortezomib. Because MM is a highly heterogeneous disease coupled wit...
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-37469 | biostudies-arrayexpress
TranscriptomicsExpression of genetic adaptability of cancer cells under treatment selection pressure in multiple myeloma patients
Series GSE25262 patients on expression side. [Exon study] 11 myeloma patients at diagnosis and relapse examined with Exon expression chip
ORGANISM(S): Homo sapiens 
2013-02-13 | E-GEOD-37414 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse multiple myeloma tumors and splenic B cells from transgenics overexpressing XBP-1s
Multiple myeloma (MM) evolves from highly prevalent premalignant condition termed Monoclonal Gammopathy of Undetermined Significance (MGUS). We report an MGUS-MM phenotype arising in transgenic mice with Emu-directed expression of the unfolded protein/ER stress response and plasma cell development ...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-6980 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to identify the molecular mechanisms whereby pDCs confer growth and drug resistance in MM cells
Multiple Myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. We performed microarray analysis to identify the molecular mechanisms whereby pDCs confer growth and drug resistance in MM cells. Co...
ORGANISM(S): Homo sapiens 
2009-07-31 | E-GEOD-17407 | biostudies-arrayexpress
TranscriptomicsPrognostic significance of copy-number alterations in multiple myeloma
Purpose Chromosomal aberrations are a hallmark of multiple myeloma but their global prognostic impact is largely unknown. Methods We performed a genome-wide analysis of malignant plasma cells from 192 newly myeloma patients using high-density, single-nucleotide polymorphism (SNP) arrays to identify...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-12896 | biostudies-arrayexpress
OtherLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Data from Massive, ID: MSV000079017. Experiment: KGG, Rep2, file: G20121009_NU_Ebert_KGG_L-1uMLen_M-No_H-20uMThal_Rep02_bRPFxn06.mzml. Published as part of Science. 2014 Jan 17;343(6168):301-5 . From the Abstract: {{i}} Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B c...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310006306 | GPMDB
Resource Reanalysis 
Genomicsena-DATASET-SC-16-09-2014-14:22:12:125-153 - samples
Description not provided
EGAD00001001014 | EGA
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