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ProteomicsHomeostatic Regulation of Nucleoporins is the Primary Driver of Nuclear Pore Biogenesis
Nuclear pore complexes (NPCs) are the multiprotein channels that control the access to the genome. Because of their critical functions, the number of NPCs that cells assemble is tightly controlled and varies between different cell types, cellular states, and in diseases. However, the mechanisms that...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD052767 | Pride
Nucleoporins 
TranscriptomicsThe Hydra magnipapillata head regeneration transcriptome
Hydra has long been studied for its remarkable ability to regenerate its head. Previous studies focusing on molecular mechanisms of axial patterning and head regeneration using a candidate gene approach have revealed a central role for the canonical Wnt pathway. We performed a global gene expression...
ORGANISM(S): Hydra vulgaris 
2014-12-13 | E-GEOD-64127 | biostudies-arrayexpress
TranscriptomicsSingle cell ATAC-seq of iPSC-derived Kidney Organoids treated with TGF-Beta 1 and GSK343 compared with vehicle treated control
This study used snATAC-seq to profile Chromatin accessibility in 26 day-old iPSC-derived kidney organoids, treated with TGFB1, the EzH2 inhibitor GSK343, a combination of both or a vehicle control for 48 hours (days 24-26) before harvesting. 2 organoids per condition were pooled and dissociated usin...
ORGANISM(S): Homo sapiens 
2023-04-30 | E-MTAB-11139 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of iPSC-derived Kidney Organoids treated with TGF-Beta 1 and GSK343 compared with vehicle treated control
This study used scRNA-seq to characterise the transcriptome in 26 day-old iPSC-derived kidney organoids, treated with TGFB1, the EzH2 inhibitor GSK343, a combination of both or a vehicle control for 48 hours (days 24-26) before harvesting. 2 organoids per condition were pooled and dissociated using ...
ORGANISM(S): Homo sapiens 
2023-04-30 | E-MTAB-11138 | biostudies-arrayexpress
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