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GenomicsNucleoporins facilitate ORC loading onto chromatin
Nucleoporins facilitate ORC loading onto chromatin
PRJNA821897 | ENA
ProteomicsHomeostatic Regulation of Nucleoporins is the Primary Driver of Nuclear Pore Biogenesis
Nuclear pore complexes (NPCs) are the multiprotein channels that control the access to the genome. Because of their critical functions, the number of NPCs that cells assemble is tightly controlled and varies between different cell types, cellular states, and in diseases. However, the mechanisms that...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD052767 | Pride
Nucleoporins 
GenomicsInvestigation of transcriptional response upon loss of individual Y-complex nucleoporins
Investigation of transcriptional response upon loss of individual Y-complex nucleoporins
PRJNA553767 | ENA
GenomicsFunctional interaction of chromatin with nucleoporins in Drosophila
Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. In yeast, they have also been proposed to interact with active genes, attracting or retaining them at the nuclear periphery. However, some NPC components (nucleoporins) in higher eukaryotes are also found in the nucleoplasm...
ORGANISM(S): Drosophila melanogaster 
2010-03-01 | GSE19307 | GEO
GenomicsNucleoporins facilitate ORC loading onto chromatin
The origin recognition complex (ORC) binds throughout the genome to initiate DNA replication. In metazoans, it is still unclear how ORC is targeted to specific loci to facilitate helicase loading and replication initiation. Here, we performed immunoprecipitations coupled with mass spectrometry for O...
ORGANISM(S): Drosophila melanogaster 
2022-10-19 | GSE199896 | GEO
GenomicsNative Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance.
Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance.
PRJNA518033 | ENA
GenomicsGene expression profiling of human DLD-1 cells after instant depletion of basket nucleoporins
Gene expression profiling of human DLD-1 cells after instant depletion of basket nucleoporins
PRJNA547746 | ENA
GenomicsGenome-wide maps of Nup98 binding in human embryonic stem cells, neural progenitors, neuron cells and lung fibroblasts
Recent evidence suggests that nucleoporins, well known components that control nucleo-cytoplasmic trafficking, have wide-ranging functions in developmental gene regulation that potentially extend beyond their role in nuclear transport. Whether the unexpected role of nuclear pore proteins in transcri...
ORGANISM(S): Homo sapiens 
2013-07-17 | E-GEOD-48996 | biostudies-arrayexpress
UnknownNucleoporins facilitate ORC loading onto chromatin.
Not available
S-EPMC10040217 | biostudies-literature
ProteomicsNucleoporins facilitate ORC loading onto chromatin
The origin recognition complex (ORC) binds throughout the genome to initiate DNA replication. In metazoans, it is still unclear how ORC is targeted to specific loci to facilitate helicase loading and replication initiation. Here, we performed immunoprecipitations coupled with mass spectrometry for O...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-19 | PXD033045 | Pride
Dna replication Drosophila Genome stability Nuclear pore 
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