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ProteomicsNeuronal differentiation of LUHMES cells is accompanied by substantial changes of the proteome
To study mechanisms of neurodegenerative diseases, neuronal cell lines are important model systems and are often differentiated into postmitotic neuron-like cells to resemble more closely primary neurons obtained from brains. One such cell line is the Lund Human Mesencephalic (LUHMES) cell line whic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-09-24 | PXD020044 | Pride
Luhmes cells Dopaminergic neuron Murine midbrain neurons Parkinson’s disease 
TranscriptomicsRNA-SEQ of Satb1-knockdown in dopaminergic neurons from the mouse mid-brain
RNA-SEQ profiling of mouse dopaminergic neurons from the mouse mid-brain, with AAV1 injections using a Satb1 shRNA-EGFP construct or a scrambed shRNA-EGFP construct Murine midbrain dopaminergic neurons with Satb1 shRNA treatment or scrambled control
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-70133 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ profiling of mouse whole midbrain and dopaminergic neurons from the mouse mid-brain
RNA-SEQ profiling of mouse whole midbrain and dopaminergic neurons from the mouse mid-brain Murine whole midbrain and murine midbrain dopaminergic neurons
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-64526 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ profiling of dopaminergic neurons from the mid-brain of mice that received intraperitoneal injections of MPTP
RNA-SEQ of dopaminergic neurons from the mid-brain of mice that received one daily intraperitoneal injection of MPTP-HCl (30 mg/kg free base per day) or saline for five consecutive days. Samples were taken 4 days. Murine midbrain dopaminergic neurons that were treated with MPTP-HCl
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-54795 | biostudies-arrayexpress
TranscriptomicsMidbrain floor plate dopamine neurons from human ESCs efficiently engraft in murine and primate models of PD
Human pluripotent stem cells (hPSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of hPSCs into specialized cells such as spinal motoneurons or midbrain dopamine (DA) neurons has been achieved. However the effective use of hPSCs for cell therap...
ORGANISM(S): Homo sapiens 
2011-11-07 | E-GEOD-32658 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ profiling of dopaminergic neurons from the substantia nigra pars compacta and ventral tegmental area regions of the mouse mid-brain
RNA-SEQ profiling of dopaminergic neurons from the substantia nigra pars compacta and ventral tegmental area regions of the mouse mid-brain Murine midbrain dopaminergic neurons from the SNpc and VTA regions
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-64452 | biostudies-arrayexpress
GenomicsMus musculus
RNA-SEQ profiling of mouse whole midbrain and dopaminergic neurons from the mouse mid-brain
PRJNA271250 | ENA
UnknownTcf12 Is Involved in Early Cell-Fate Determination and Subset Specification of Midbrain Dopamine Neurons.
Not available
S-EPMC5671939 | biostudies-literature
TranscriptomicsMidbrain floor plate dopamine neurons from human ESCs efficiently engraft in murine and primate models of PD
Human pluripotent stem cells (hPSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of hPSCs into specialized cells such as spinal motoneurons or midbrain dopamine (DA) neurons has been achieved. However the effective use of hPSCs for cell therapy...
ORGANISM(S): Homo sapiens 
2011-11-07 | GSE32658 | GEO
UnknownAcid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage.
Not available
S-EPMC1544094 | biostudies-literature
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