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ProteomicsCharacterization of gastric tumor organoids with specific oncogenic pathway activations
Gastric cancer ranks the fifth most common malignancy and the third leading cause of cancer related death worldwide. Classical chemotherapy is still the standard treatment in advanced stages, with only two targeted therapies currently in clinical use. Several targeted trials have failed, likely due ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-22 | PXD022015 | Pride
Phospho proteome signature Proteome signature Murine tumor organoid models Gastric cancer 
GenomicsOrganoid modeling of the tumor immune microenvironment
Organoid modeling of the tumor immune microenvironment
PRJNA436710 | ENA
GenomicsHnf4a regulated transcriptome in organoid cultures derived from murine pancreas where HNnf4a is deleted after tumor initiation. [organoid]
Hnf4a regulated transcriptome in organoid cultures derived from murine pancreas where HNnf4a is deleted after tumor initiation. [organoid]
PRJNA574922 | ENA
UnknownMurine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma.
Not available
S-EPMC7766822 | biostudies-literature
ProteomicsOrganoid-trasplant model systems to study in vivo the effects of obesity on the pancreatic carcinogenesis
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality among adults in developed countries. The discovery of the most common genetic alterations as well as the development of organoids models of pancreatic cancer have provided insight into the fundamental path...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018362 | Pride
Carcinogenesis Obesity Organoid models Adipokines Pancreatic cancer 
UnknownOrganoid models of human and mouse ductal pancreatic cancer.
Not available
S-EPMC4334572 | biostudies-literature
TranscriptomicsOrganoid modeling of the tumor immune microenvironment
The interaction of neoplastic cells with their tumor microenvironment (TME) is required for cancer progression. However, in vitro cancer models, including recent in vitro 3-dimensional (3D) organoid cultures of primary human tumors, are typically comprised exclusively of neoplastic epithelium, with ...
ORGANISM(S): Homo sapiens 
2018-12-13 | GSE111360 | GEO
TranscriptomicsIn vivo intratumoral Heterogeneity in a dish: Scalable Forebrain Organoid Models of Embryonal Brain Tumors for High-Throughput Personalized Drug Discovery (murine subset)
Embryonal brain tumors (EBTs), arising during early brain development, present significant challenges in understanding pathogenesis and developing treatments. This study explores the efficacy of forebrain organoid models in replicating the complexities of the EBT microenvironment. We established an ...
ORGANISM(S): Mus musculus 
2025-11-13 | GSE270018 | GEO
GenomicsOrthotopic CRC organoid transplantation in mice: A novel model for the study and treatment of peritoneal carcinomatosis [Whole-tumor scRNA-Seq]
Orthotopic CRC organoid transplantation in mice: A novel model for the study and treatment of peritoneal carcinomatosis [Whole-tumor scRNA-Seq]
PRJNA910092 | ENA
TranscriptomicsIn vivo intratumoral Heterogeneity in a dish: Scalable Forebrain Organoid Models of Embryonal Brain Tumors for High-Throughput Personalized Drug Discovery (human+murine organoids subset)
Embryonal brain tumors (EBTs), arising during early brain development, present significant challenges in understanding pathogenesis and developing treatments. This study explores the efficacy of forebrain organoid models in replicating the complexities of the EBT microenvironment. We established an ...
ORGANISM(S): Homo sapiens Mus musculus 
2025-11-13 | GSE270064 | GEO
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