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MetabolomicsPromoting of microplastic intake on gastric epithelial cell carcinogenesis and its molecular mechanism.

The core objective of this study is to clarify the promoting effect of oral ingestion of microplastics on gastric epithelial cell carcinogenesis, systematically decipher the underlying molecular regulatory mechanisms, focus on investigating the key molecular targets involved in oxidative stress i...

2026-01-06 | MTBLS13588 | MetaboLights
MetabolomicsMetabolic reprogramming is an initial step in pancreatic carcinogenesis that can be targeted to inhibit acinar-to-ductal metaplasia

Metabolic reprogramming is a hallmark of cancer and is crucial for cancer progression, making it an attractive therapeutic target. Understanding the role of metabolic reprogramming in cancer initiation could help identify prevention strategies. To address this, we investigated metabolism during a...

2024-05-31 | MTBLS9772 | MetaboLights
MetabolomicsEffects of bariatric and antibiotic treatment surgery on mammary carcinogenesis
Not available
ORGANISM(S): Mus musculus 
ST000728 | MetabolomicsWorkbench
MetabolomicsThe effects of obesity microbiota produced metabolites on colorectal carcinogenesis in murine models
Not available
ORGANISM(S): Mus musculus 
ST002193 | MetabolomicsWorkbench
MetabolomicsNuclear magnetic resonance-based metabolomics approach to evaluate the prevention effect of Camellia nitidissima Chi on colitis-associated carcinogenesis
Not available
ORGANISM(S): Mus musculus 
ST000782 | MetabolomicsWorkbench
ProteomicsLoss of colonic primary cilia promotes inflammation and carcinogenesis
Primary cilia (PC) are important signaling hubs in cells and we explored their role in colorectal cancer (CRC) and colitis. In the colon we found PC to be mostly present on different subtypes of fibroblasts and exposure of mice to either chemically induced colitis-associated colon carcinogenesis (CA...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD033440 | Pride
Colon carcinogenesis Inflammation Primary cilia Colonic fibroblasts Colitis 
UnknownProtective role of cathepsin L in mouse skin carcinogenesis.
Not available
S-EPMC3155742 | biostudies-literature
ProteomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis
PTEN, a widely investigated tumor suppressor, has at least two longer translational variants, PTEN and . However, the regulation and precise roles of endogenous PTEN/ in tumorigenesis remain greatly unknown. Here we show that USP9X and FBXW11 selectively regulate the stability of PTEN/ but not PTEN ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD013196 | Pride
Ptena  ptenb  pten  usp9x  fbxw11  ubiquitination wdr5  carcinogenesis 
ClinicalPreventive Strategies in Colorectal Carcinogenesis Production and Meat Processing
Colorectal Cancer is, in non-smokers for both sex, first cause of cancers mortality in Western country. The main risk factors associated with colorectal cancer depend of lifestyle, and processed meat and red meat could be involved in carcinogenesis by cytotoxic and genotoxic compound linked to lipid...
2192252 | ecrin-mdr-crc
ProteomicsOrganoid-trasplant model systems to study in vivo the effects of obesity on the pancreatic carcinogenesis
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality among adults in developed countries. The discovery of the most common genetic alterations as well as the development of organoids models of pancreatic cancer have provided insight into the fundamental path...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018362 | Pride
Carcinogenesis Obesity Organoid models Adipokines Pancreatic cancer 
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