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GenomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis [ChIP-seq 2]
PTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis [ChIP-seq 2]
PRJNA559009 | ENA
GenomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis [RNA-seq 2]
PTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis [RNA-seq 2]
PRJNA559007 | ENA
GenomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis [ChIP-seq 2]
We report that USP9X and FBXW11 selectively regulate the stability of PTENa/b but not PTEN proteins by deubiquitination and ubiquitination respectively. USP9X promotes and FBXW11 suppresses tumorigenesis mediated by PTENa/b. In contrast to the current paradigm for PTEN as a tumor suppressor, PTENa/b...
ORGANISM(S): Homo sapiens 
2019-10-17 | GSE135478 | GEO
TranscriptomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis [RNA-seq 2]
We report that USP9X and FBXW11 selectively regulate the stability of PTENa/b but not PTEN proteins by deubiquitination and ubiquitination respectively. USP9X promotes and FBXW11 suppresses tumorigenesis mediated by PTENa/b. In contrast to the current paradigm for PTEN as a tumor suppressor, PTENa/b...
ORGANISM(S): Homo sapiens 
2019-10-17 | GSE135477 | GEO
UnknownPTEN redundancy: overexpressing lpten, a homolog of Dictyostelium discoideum ptenA, the ortholog of human PTEN, rescues all behavioral defects of the mutant ptenA-.
Not available
S-EPMC4172592 | biostudies-literature
UnknownPtena and ptenb genes play distinct roles in zebrafish embryogenesis.
Not available
S-EPMC2611959 | biostudies-literature
Genomics
RNA-seq of lung tissues in WT and PTENa-/- mice post LCMV infection.
PRJNA512263 | ENA
ProteomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis
PTEN, a widely investigated tumor suppressor, has at least two longer translational variants, PTEN and . However, the regulation and precise roles of endogenous PTEN/ in tumorigenesis remain greatly unknown. Here we show that USP9X and FBXW11 selectively regulate the stability of PTEN/ but not PTEN ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD013196 | Pride
Ptena  ptenb  pten  usp9x  fbxw11  ubiquitination wdr5  carcinogenesis 
UnknownZebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity.
Not available
S-EPMC7349019 | biostudies-literature
UnknownImpaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten.
Not available
S-EPMC5743786 | biostudies-literature
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