Zebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity.

ABSTRACT: The PTEN (phosphatase and TENsin homolog on chromosome 10) gene encodes a bifunctional phosphatase that acts as a tumor suppressor. However, PTEN has been implicated in different immune processes, including autophagy, inflammation, regulation of natural killer (NK) cell cytolytic activity and type I interferon responses. Unlike mammals, zebrafish possess two pten genes (ptena and ptenb). This study explores the involvement of both zebrafish pten genes in antiviral defense. Although ptena-/- and ptenb-/- larvae were more susceptible to Spring viremia of carp virus (SVCV), the viral replication rate was lower in the mutant larvae than in the wild-type larvae. We observed that both mutant lines showed alterations in the transcription of numerous genes, including those related to the type I in

SUBMITTER: Pereiro P 

PROVIDER: S-EPMC7349019 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature