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MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
UnknownIntranasal Oxytocin Improves Lean Muscle Mass and Lowers LDL Cholesterol in Older Adults with Sarcopenic Obesity: A Pilot Randomized Controlled Trial.
Not available
S-EPMC8567747 | biostudies-literature
UnknownTribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.
Not available
S-EPMC3707125 | biostudies-literature
TranscriptomicsTranscription profiling of mouse colon carcinomas over-expressing c-Myc
MycRas vs Ras colon carcinoma. Human adenocarcinomas commonly harbor mutations in the Ki-Ras and c-Myc proto-oncogenes and the trp53 tumor suppressor gene. All three genetic lesions are potentially pro-angiogenic, since they sustain production of the vascular endothelial growth factor (VEGF). Yet m...
ORGANISM(S): Mus musculus 
2006-09-08 | E-MEXP-757 | biostudies-arrayexpress
GenomicsSubtelomeric p53 Binding Prevents Accumulation of DNA Damage at Human Telomeres
Telomeres and tumor suppressor protein TP53 (p53) function in genome protection, but a direct role of p53 at telomeres has not yet been described. Here, we have identified non-canonical p53 binding sites within the human subtelomeres that suppress the accumulation of DNA damage at telomeric repeat ...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-75528 | biostudies-arrayexpress
UnknownDeciphering the Substrate Specificity of SbnA, the Enzyme Catalyzing the First Step in Staphyloferrin B Biosynthesis.
Not available
S-EPMC5084695 | biostudies-literature
Unknown149. Immunogenicity, Safety, and Post-hoc Efficacy Assessment of the Adjuvanted Recombinant Zoster Vaccine in Adults with Hematologic Malignancies: A Phase 3, Randomized Clinical Trial
Not available
S-EPMC6252456 | biostudies-literature
UnknownFactors associated with weight gain during COVID-19 pandemic: A global study.
Not available
S-EPMC10118192 | biostudies-literature
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
UnknownOxygen tension modulates the effects of TNFα in compressed chondrocytes.
Not available
S-EPMC5209429 | biostudies-literature
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