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TranscriptomicsA genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.
It is now well established that the E- and Id-protein axis regulates multiple steps in lymphocyte development. However, it remains unknown as to how E- and Id-proteins mechanistically enforce and maintain the naïve T cell fate. Here we show that Id2 and Id3 suppressed the development and expansion o...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64779 | biostudies-arrayexpress
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
TranscriptomicsIdentification of E47 targets
In maturing T-lineage cells, the helix-loop-helix protein E47 has been shown to enforce a critical proliferation and developmental checkpoint commonly referred to as β selection. To examine how E47 regulates cellular expansion and developmental progression, we have used an E2A deficient lymphoma c...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-4784 | biostudies-arrayexpress
GenomicsOpposing roles of E2A and Id3 that orchestrate and enforce the naive T cell fate
It is established that E2A and its antagonist, Id3, modulate developmental progression at the pre-TCR and TCR checkpoints. Here we show at a global scale how E2A promotes commitment to the T cell lineage and how pre-TCR mediated signalling affects E2A genome-wide occupancy. We find aberrant develo...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-30518 | biostudies-arrayexpress
GenomicsEstablishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (ChIP-Seq dataset)
Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how epigenetic marks are established and maintained during developmental progression, we have generated long-term cult...
ORGANISM(S): Mus musculus 
2011-09-01 | E-GEOD-30858 | biostudies-arrayexpress
GenomicsNuclear Morphology is Instructed by the Loop Extrusion Program [HiC]
Nuclear Morphology is Instructed by the Loop Extrusion Program [HiC]
PRJNA970727 | ENA
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
GenomicsBrg1 activates enhancer repertoires to establish B cell identity and modulate cell growth
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros. However, how the genome-wide binding patterns of these regulators are modulated during B-lineage development remains to be determined. Here, we found that in lymphoid pr...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-66978 | biostudies-arrayexpress
GenomicsMus musculus
Establishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (gene expression dataset 1)
PRJNA154599 | ENA
TranscriptomicsId2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We ...
ORGANISM(S): Mus musculus 
2014-06-29 | E-GEOD-57682 | biostudies-arrayexpress
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